Striha Megan, Edjoc Rojiemiahd, Bresee Natalie, Atchessi Nicole, Waddell Lisa, Bennett Terri-Lyn, Thompson Emily, El Jaouhari Maryem, Bonti-Ankomah Samuel
Health Security and Regional Operations Branch, Public Health Agency of Canada, Ottawa, ON.
Children's Hospital of Eastern Ontario, Ottawa, ON.
Can Commun Dis Rep. 2021 Nov 10;47(11):466-472. doi: 10.14745/ccdr.v47i11a04.
Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19) is an emerging condition that was first identified in paediatrics at the onset of the COVID-19 pandemic. The condition is also known as pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS or PIMS), and multiple definitions have been established for this condition that share overlapping features with Kawasaki Disease and toxic shock syndrome.
A review was conducted to identify literature describing the epidemiology of MIS-C, published up until March 9, 2021. A database established at the Public Health Agency of Canada with COVID-19 literature was searched for articles referencing MIS-C, PIMS or Kawasaki Disease in relation to COVID-19.
A total of 195 out of 988 articles were included in the review. The median age of MIS-C patients was between seven and 10 years of age, although children of all ages (and adults) can be affected. Multisystem inflammatory syndrome in children disproportionately affected males (58% patients), and Black and Hispanic children seem to be at an elevated risk for developing MIS-C. Roughly 62% of MIS-C patients required admission to an intensive care unit, with one in five patients requiring mechanical ventilation. Between 0% and 2% of MIS-C patients died, depending on the population and available interventions.
Multisystem inflammatory syndrome in children can affect children of all ages. A significant proportion of patients required intensive care unit and mechanical ventilation and 0%-2% of cases resulted in fatalities. More evidence is needed on the role of race, ethnicity and comorbidities in the development of MIS-C.
与2019冠状病毒病（COVID-19）相关的儿童多系统炎症综合征（MIS-C）是一种新出现的病症，在COVID-19大流行开始时首次在儿科中被发现。该病症也被称为与严重急性呼吸综合征冠状病毒2时间相关的儿童炎症性多系统综合征（PIMS-TS或PIMS），并且已经为这种与川崎病和中毒性休克综合征具有重叠特征的病症建立了多种定义。
进行了一项综述，以确定截至2021年3月9日发表的描述MIS-C流行病学的文献。在加拿大公共卫生局建立的一个包含COVID-19文献的数据库中，搜索了提及与COVID-19相关的MIS-C、PIMS或川崎病 的文章。
该综述共纳入了988篇文章中的195篇。MIS-C患者的中位年龄在7至10岁之间，不过各年龄段（以及成人）的儿童都可能受到影响。儿童多系统炎症综合征对男性的影响尤为严重（占患者的58%），黑人和西班牙裔儿童似乎患MIS-C的风险更高。大约62%的MIS-C患者需要入住重症监护病房，五分之一的患者需要机械通气。根据人群和可用干预措施的不同，0%至2%的MIS-C患者死亡。
儿童多系统炎症综合征可影响各年龄段的儿童。很大一部分患者需要重症监护和机械通气，0%-2%的病例导致死亡。关于种族、族裔和合并症在MIS-C发生中的作用，还需要更多证据。
