Rosińska-Więckowicz Anna, Jałowska Magdalena, Bowszyc-Dmochowska Monika, Dmochowski Marian
Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznań, Poland.
Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznań, Poland.
Front Med (Lausanne). 2021 Nov 22;8:760823. doi: 10.3389/fmed.2021.760823. eCollection 2021.
Bullous pemphigoid (BP) is a cutaneous disease triggered by numerous stimuli, where genetic milieu-influenced autoimmunity to hemidesmosomal proteins, namely, BP180 and/or BP230 initiate an inflammation leading to dermal-epidermal junction (DEJ) enzymatic pathological remodelling. Here, to the best of our knowledge, we present the first case of an infantile BP apparently triggered by COVID-19. BP should be included in differential diagnosis of infantile rashes showing blisters or vesicles or both as well as their prodromal and evolutionary lesions. Possible triggers, such as coronavirus disease 2019 (COVID-19), of BP in infancy should be identified and properly dealt with.
大疱性类天疱疮(BP)是一种由多种刺激引发的皮肤病,其中受遗传环境影响的对半桥粒蛋白(即BP180和/或BP230)的自身免疫反应引发炎症,导致真皮-表皮连接(DEJ)酶促病理重塑。在此,据我们所知,我们报告了首例显然由新型冠状病毒肺炎(COVID-19)引发的婴儿期BP病例。对于出现水疱或脓疱或两者皆有的婴儿皮疹及其前驱和演变性病变,应将BP纳入鉴别诊断。应识别并妥善处理婴儿期BP可能的触发因素,如2019冠状病毒病(COVID-19)。