Department of Otorhinolaryngology-Head and Neck Surgery, Osaka Medical and Pharmaceutical University, Takatsuki-City 569-8686, Japan.
Department of Innovative Medicine, Graduate School of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki-City 569-8686, Japan.
Int J Mol Sci. 2021 Nov 23;22(23):12613. doi: 10.3390/ijms222312613.
Incomplete excision of pleomorphic adenoma (PA) may result in recurrent pleomorphic adenoma (RPA). Furthermore, long-term neglected PA may become carcinoma ex pleomorphic adenoma (CXPA). In the present study, the relationships between mast cell-derived chymase and these tumors were examined. The tumor tissues of PA consisted of either or both glandular and fibrotic structures. Histological features of RPA were almost similar to those of PA, except that they showed multinodular structures. CXPA is composed of a mixture of PA and carcinoma. The main stromal cells in PA were myofibroblasts, whereas fibroblasts constituted the main cellular portion in the stromal tissue of RPA. Cancer-associated fibroblasts (CAFs) were present abundantly in CXPA. With increased VEGF expression, neovascularization tended to increase in RPA or CXPA. Compared with PA, chymase-positive mast cells, as well as chymase gene expression, were increased in the tumor tissues from patients with RPA or CXPA. SCF, TGFβ1, and PCNA-positive staining was widely observed in these tumor tissues. The above results suggest that mast cell-derived chymase through its direct or cooperative effects with other mediators may participate in the pathophysiology of RPA and CXPA.
多形性腺瘤（PA）的不完全切除可能导致复发性多形性腺瘤（RPA）。此外，长期被忽视的 PA 可能发展为癌在多形性腺瘤中（CXPA）。在本研究中，研究了肥大细胞衍生的糜酶与这些肿瘤之间的关系。PA 的肿瘤组织由腺体和纤维性结构组成。RPA 的组织学特征几乎与 PA 相似，只是它们表现为多结节结构。CXPA 由 PA 和癌的混合物组成。PA 中的主要基质细胞是肌成纤维细胞，而纤维母细胞构成 RPA 基质组织中的主要细胞部分。癌相关成纤维细胞（CAFs）在 CXPA 中大量存在。随着 VEGF 表达的增加，RPA 或 CXPA 中的新生血管化倾向于增加。与 PA 相比，RPA 或 CXPA 患者肿瘤组织中 Chymase 阳性肥大细胞及其 Chymase 基因表达增加。这些肿瘤组织中广泛观察到 SCF、TGFβ1 和 PCNA 阳性染色。上述结果表明，肥大细胞衍生的糜酶可能通过其直接或协同作用与其他介质一起参与 RPA 和 CXPA 的病理生理过程。
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