Department of Dermatology and Venerology, University of Tartu, 31 Raja, 50417 Tartu, Estonia.
Dermatology Clinic, Tartu University Hospital, 31 Raja, 50417 Tartu, Estonia.
Int J Mol Sci. 2021 Dec 2;22(23):13056. doi: 10.3390/ijms222313056.
The melanocortin system is a major regulator of stress responses in the skin and is responsible for the induction of melanin synthesis through activation of melanogenesis enzymes. The expression of both melanocortin system genes and melanogenesis enzyme genes is altered in psoriasis, and the focus here was on twelve genes related to the signal transduction between them. Additionally, five endogenous opioid system genes that are involved in cutaneous inflammation were examined. Quantitative real-time-PCR was utilized to measure mRNA expression in punch biopsies from lesional and non-lesional skin of psoriasis patients and from the skin of healthy control subjects. Most of the genes related to melanogenesis were down-regulated in patients (CREB1, MITF, LEF1, USF1, MAPK14, ICAM1, PIK3CB, RPS6KB1, KIT, and ATRN). Conversely, an up-regulation occurred in the case of opioids (PENK, PDYN, and PNOC). The suppression of genes related to melanogenesis is in agreement with the reported reduction in pigmentation signaling in psoriatic skin and potentially results from the pro-inflammatory environment. The increase in endogenous opioids can be associated with their involvement in inflammatory dysregulation in psoriasis.
黑色素皮质素系统是皮肤应激反应的主要调节因子，通过激活黑色素生成酶来诱导黑色素合成。银屑病中黑色素皮质素系统基因和黑色素生成酶基因的表达都发生了改变，本研究重点关注了它们之间信号转导相关的 12 个基因。此外，还研究了五个参与皮肤炎症的内源性阿片系统基因。通过定量实时 PCR 测量了银屑病患者皮损和非皮损皮肤以及健康对照受试者皮肤的活检组织中 mRNA 的表达。与黑色素生成相关的大多数基因在患者中下调（CREB1、MITF、LEF1、USF1、MAPK14、ICAM1、PIK3CB、RPS6KB1、KIT 和 ATRN）。相反，阿片类物质的表达上调（PENK、PDYN 和 PNOC）。与黑色素生成相关基因的抑制与报道的银屑病皮肤中色素沉着信号的减少一致，可能是由促炎环境引起的。内源性阿片类物质的增加可能与其在银屑病炎症失调中的参与有关。
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