Biological Investigation of Amaryllidaceae Alkaloid Extracts from the Bulbs of Collected in the Senegalese Flora.

Amaryllidaceae plants are rich in alkaloids with biological properties. is an Amaryllidaceae species widely used in African folk medicine to treat several diseases such as central nervous system disorders, tumors, and microbial infections, and it is used to heal wounds. The current investigation explored the biological properties of alkaloid extracts from bulbs of collected in the Senegalese flora. Alkaloid extracts were analyzed and identified by chromatography and mass spectrometry. Alkaloid extracts from displayed pleiotropic biological properties. Cytotoxic activity of the extracts was determined on hepatocarcinoma Huh7 cells and on acute monocytic leukemia THP-1 cells, while agar diffusion and microdilution assays were used to evaluate antibacterial activity. Antiviral activity was measured by infection of extract-treated cells with dengue virus (DENV) and human immunodeficiency virus-1 (HIV-1) reporter vectors. Cytotoxicity and viral inhibition were the most striking of 's extract activities. Importantly, non-cytotoxic concentrations were highly effective in completely preventing DENV replication and in reducing pseudotyped HIV-1 infection levels. Our results show that is a rich source of molecules for the potential discovery of new treatments against various diseases. Herein, we provide scientific evidence to rationalize the traditional uses of for wound treatment as an anti-dermatosis and antiseptic agent.