[Interaction analysis of the influence of different factors and benzene exposure on the white blood cell count of workers].

To explore the main influencing factors of leucopenia in benzene workers. The data of 514 benzene hazardous enterprises and 97 non benzene hazardous enterprises in 16 municipal districts of Tianjin from January to December 2019 were collected. A total of 16113 benzene exposed workers and 5817 non benzene exposed workers were included in the study. The occupational health examination data of workers during on-the-job were analyzed, and they were divided into white blood cell count reduction group and white blood cell count normal group. Additive interaction was used to evaluate the effects of workers' general situation, occupational history, enterprise information and benzene exposure on leukocyte count reduction. The age and length of service of workers in the white blood cell count reduction group were higher than those in the white blood cell count normal group (=-3.411, -4.539, <0.01) . The detection rate of white blood cell count reduction in women was higher than that in men (χ(2)=211.631, <0.01) . The detection rate of white blood cell count reduction in workers in enterprises located in urban areas, classified as manufacturing and small and micro enterprises was higher than that in workers in suburbs, non manufacturing and large and medium-sized enterprises (χ(2)=8.039, 4.232, 37.478, <0.05) . The additive interaction analysis of the influencing factors of white blood cell count reduction showed that there was additive interaction between gender and benzene exposure, the relative excess risk ratio () , attribution ratio () and interaction index () were 3.789 (95%: 2.280-5.299) , 0.571 (95%: 0.414-0.726) and 3.045 (95%: 1.699-5.459) , respectively. The management of benzene operation in the production environment of small and micro manufacturing enterprises in Tianjin should be strengthened, as well as the personal protective articles and occupational health protection measures for female operators, so as to protect the health of operators and prevent the occurrence of occupational diseases.