Sheibani K, Sohn C C, Burke J S, Winberg C D, Wu A M, Rappaport H
Am J Pathol. 1986 Aug;124(2):310-8.
Monocytoid B lymphocytes (MBLs), originally described as part of the histologic picture of toxoplasmic lymphadenitis, have been recognized as a reactive component in a variety of lymph node disorders. The authors now report 3 cases of non-Hodgkin's lymphoma in which a multidisciplinary approach allowed them to confirm the existence of a malignant lymphoma composed of the neoplastic counterpart of the MBLs found in nonneoplastic disorders. In all 3 cases, the lymphoma was composed of a relatively monomorphous infiltrate of atypical MBLs that had rather uniform-appearing nuclei and had well-defined, moderately abundant pale cytoplasm. The pattern of lymph node involvement in all 3 cases was predominantly sinusoidal and interfollicular. The neoplastic lymphoid cells were strongly positive for B-cell-restricted antigens; the light- and heavy-chain phenotypes were kappa-IgM (2 cases) and kappa-IgG (1 case). In all 3 cases, rearrangement of heavy- and/or light-chain genes was clearly identified by Southern blot hybridization. The name "monocytoid B-cell lymphoma" is proposed for this newly described malignant B-cell neoplasm.
单核细胞样B淋巴细胞（MBLs）最初被描述为弓形虫性淋巴结炎组织学表现的一部分，现已被认为是多种淋巴结疾病中的一种反应性成分。作者现报告3例非霍奇金淋巴瘤，采用多学科方法使他们能够证实存在一种由非肿瘤性疾病中发现的MBLs的肿瘤对应物组成的恶性淋巴瘤。在所有3例病例中，淋巴瘤由相对单一形态的非典型MBLs浸润组成，这些细胞的细胞核外观相当一致，细胞质清晰、中等丰富且呈淡染。所有3例病例中淋巴结受累模式主要为窦状和滤泡间。肿瘤性淋巴细胞对B细胞限制性抗原呈强阳性；轻链和重链表型为κ-IgM（2例）和κ-IgG（1例）。在所有3例病例中，通过Southern印迹杂交清楚地鉴定出重链和/或轻链基因的重排。为此新描述的恶性B细胞肿瘤提出“单核细胞样B细胞淋巴瘤”这一名称。
