Lovett J, Nyberg L M, Brown S, Mathur S
Am J Reprod Immunol Microbiol. 1986 Jun;11(2):65-8. doi: 10.1111/j.1600-0897.1986.tb00031.x.
The effect of a short pulse therapy with cyclosporine on the production of vasectomy-induced cytotoxic sperm antibodies was studied in Lewis rats. Cyclosporine at a dose of 10 mg/kg was administered once daily for 7 days before and 7 days after vasectomy (group A), for 7 days before vasectomy (group B), and for 7 days after vasectomy (group C). Ten rats were studied in each group for a period of 5 weeks. Ten rats were vasectomized and untreated with cyclosporine (group U). All animals in this group developed high titers of cytotoxic sperm antibodies at the end of the first week after vasectomy (primary antibody response). In contrast, all the treated rats of groups A, B, and C had a normal range of sperm antibody titers. By the third week, six of nine rats in the post-treated group C had significant cytotoxic sperm antibody titers, while the other groups had normal antibody titers. In the fourth week, all the rats of groups A and B continued to have normal sperm antibody titers of less than or equal to 16, while most animals in groups C (78%) and U (63%) had significant cytotoxic sperm antibody titers. It is concluded that prevasectomy treatment with cyclosporine may significantly reduce or delay the production of cytotoxic sperm antibodies in Lewis rats.
在Lewis大鼠中研究了环孢素短脉冲疗法对输精管结扎诱导的细胞毒性精子抗体产生的影响。在输精管结扎前7天和结扎后7天，每天一次给予剂量为10mg/kg的环孢素（A组）；在输精管结扎前7天给药（B组）；在输精管结扎后7天给药（C组）。每组研究10只大鼠，为期5周。10只大鼠进行输精管结扎且未用环孢素治疗（U组）。该组所有动物在输精管结扎后第一周结束时均产生了高滴度的细胞毒性精子抗体（初次抗体反应）。相比之下，A、B和C组所有接受治疗的大鼠精子抗体滴度均在正常范围内。到第三周时，C组（治疗后组）9只大鼠中有6只具有显著的细胞毒性精子抗体滴度，而其他组抗体滴度正常。在第四周时，A组和B组所有大鼠的精子抗体滴度持续正常，小于或等于16，而C组（78%）和U组（63%）的大多数动物具有显著的细胞毒性精子抗体滴度。得出的结论是，输精管结扎前用环孢素治疗可能会显著降低或延迟Lewis大鼠中细胞毒性精子抗体的产生。
