Department of Pulmonary Medicine, Xinglin Branch of The First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China.
Department of Cardiovascular Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China.
Can Respir J. 2021 Nov 30;2021:8492468. doi: 10.1155/2021/8492468. eCollection 2021.
To determine whether the neutrophil-to-lymphocyte ratio (NLR) aids in the detection of obstructive sleep apnea (OSA) in patients with type B aortic dissection (TBAD).
324 patients with TBAD or type B aortic intramural hematoma (TB-AIMH) underwent an overnight sleep study. We divided the eligible 256 studied subjects into three groups: group A ( = 109, TBAD patients with OSA), group B ( = 68, TB-AIMH patients with OSA), and group C ( = 79, TBAD patients without OSA). Baseline characteristics, biochemical and sleep parameters, and STOP-Bang questionnaire scores were collected. To assess the predictive efficacy of potential variables, multivariate logistic regression analysis and receiver operating characteristic (ROC) curves were used.
The study found that about 58% of TBAD patients and 54% of TB-AIMH patients had OSA, a majority of whom had moderate to severe OSA (95.41% and 89.71%, respectively). In the comparison of sleep parameters between patients with TBAD and TB-AIMH, no other than apnea and hypopnea index (AHI) made a significant difference. The multivariate logistic regression analysis showed that neutrophil-to-lymphocyte ratio (NLR) (odds ratio (OR): 3.614, 95% confidence interval (CI): 2.273-5.748, and < 0.05) and STOP-Bang scores (OR: 1.97, 95% CI: 1.34-2.90, and < 0.05) were both independent predictors for OSA in patients with TBAD. ROC curves showed NLR had higher sensitivity (65% versus 59%) and specificity (86% versus 57%) for OSA than the STOP-Bang questionnaire. Furthermore, NLR was positively correlated with AHI through the Spearman test ( = 0.398 and < 0.05).
NLR was an independent predictor of OSA in TBAD patients with higher sensitivity and specificity than the STOP-Bang questionnaire, and it was positively associated with AHI. NLR may aid in the diagnosis and risk stratification of OSA in TBAD patients.
确定中性粒细胞与淋巴细胞比值（NLR）是否有助于检测 B 型主动脉夹层（TBAD）患者的阻塞性睡眠呼吸暂停（OSA）。
324 例 TBAD 或 B 型主动脉壁内血肿（TB-AIMH）患者进行了一夜睡眠研究。我们将符合条件的 256 名研究对象分为三组：A 组（ = 109，TBAD 合并 OSA 患者）、B 组（ = 68，TB-AIMH 合并 OSA 患者）和 C 组（ = 79，TBAD 不合并 OSA 患者）。收集基线特征、生化和睡眠参数以及 STOP-Bang 问卷评分。为了评估潜在变量的预测效能，使用多元逻辑回归分析和受试者工作特征（ROC）曲线。
研究发现，约 58%的 TBAD 患者和 54%的 TB-AIMH 患者患有 OSA，其中大多数为中重度 OSA（分别为 95.41%和 89.71%）。在 TBAD 患者和 TB-AIMH 患者的睡眠参数比较中，除了呼吸暂停低通气指数（AHI）外，其他参数均无显著差异。多元逻辑回归分析显示，中性粒细胞与淋巴细胞比值（NLR）（比值比（OR）：3.614，95%置信区间（CI）：2.273-5.748，和 < 0.05）和 STOP-Bang 评分（OR：1.97，95%CI：1.34-2.90，和 < 0.05）均为 TBAD 患者 OSA 的独立预测因子。ROC 曲线显示，NLR 对 OSA 的敏感性（65%对 59%）和特异性（86%对 57%）均高于 STOP-Bang 问卷。此外，NLR 通过 Spearman 检验与 AHI 呈正相关（ = 0.398 和 < 0.05）。
NLR 是 TBAD 患者 OSA 的独立预测因子，其敏感性和特异性均高于 STOP-Bang 问卷，且与 AHI 呈正相关。NLR 可能有助于诊断和分层 TBAD 患者的 OSA 风险。
