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使用吡啶修饰的基质通过基质辅助激光解吸电离飞行时间质谱法表征低聚羟基硅油

Characterizing Oligomeric Hydroxyl Silicon Oils by MALDI-TOF MS With the Pyridine-Modified Matrix.

作者信息

Zhang Xiaoxiao, Wang Yan, Hu Yiqiu, Guo Cheng, Li Chenghua, Jiang Kezhi

机构信息

College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Normal University, Hangzhou, China.

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Front Chem. 2021 Nov 23;9:755174. doi: 10.3389/fchem.2021.755174. eCollection 2021.

DOI:10.3389/fchem.2021.755174
PMID:34888293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8650622/
Abstract

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF) is a powerful technique for analysis of various polymers, but it is still very difficult to characterize silicone oil due to its poor ionization efficiency. In this work, oligomeric hydroxyl silicone oils were successfully characterized by MALDI-TOF, by using pyridine-modified 2,5-dihydroxylbenzoic acid (DHB) as the matrix. Furthermore, the mixed crystal of DHB and hydroxyl silicone oil was analyzed by scanning electron microscopy (SEM) and energy disperse spectroscopy (EDS), and the analytical results verified that modification with pyridine could remarkably improve the solubility of hydroxyl silicone oil in DHB, leading to the enhancement of its ionization efficiency in MALDI. The analysis of the MS spectra of a series of hydroxyl silicone oils indicated that they tended to be ionized by the attachment with Na, and the average molecular weight and the degree of polymerization were measured for several oligomeric hydroxyl silicon oils.

摘要

基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）是分析各种聚合物的强大技术，但由于硅油的电离效率低，对其进行表征仍然非常困难。在这项工作中，通过使用吡啶修饰的2,5-二羟基苯甲酸（DHB）作为基质，成功地用MALDI-TOF对低聚羟基硅油进行了表征。此外，通过扫描电子显微镜（SEM）和能量色散光谱（EDS）对DHB与羟基硅油的混合晶体进行了分析，分析结果证实，吡啶修饰可以显著提高羟基硅油在DHB中的溶解度，从而提高其在MALDI中的电离效率。一系列羟基硅油的质谱分析表明，它们倾向于通过与Na结合而被电离，并测定了几种低聚羟基硅油的平均分子量和聚合度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/c4ec33db1a92/fchem-09-755174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/9c98c1187c92/fchem-09-755174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/35134b672126/fchem-09-755174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/f80d2a73a229/fchem-09-755174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/e963fe1bfd03/fchem-09-755174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/09da2b36c043/fchem-09-755174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/dd62885e43f5/fchem-09-755174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/c4ec33db1a92/fchem-09-755174-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/9c98c1187c92/fchem-09-755174-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/35134b672126/fchem-09-755174-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/f80d2a73a229/fchem-09-755174-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/e963fe1bfd03/fchem-09-755174-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/09da2b36c043/fchem-09-755174-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/dd62885e43f5/fchem-09-755174-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0cb/8650622/c4ec33db1a92/fchem-09-755174-g007.jpg

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本文引用的文献

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