Department of Dermatology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Physician Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Pediatr Dermatol. 2022 Jan;39(1):145-146. doi: 10.1111/pde.14876. Epub 2021 Dec 9.
Actinic prurigo is a rare pruritic photodermatosis. We report the use of Polypodium leucotomos extract in an 11-year-old female patient with actinic prurigo, resulting in a significant attenuation of her disease without development of adverse effects to date. Polypodium leucotomos exerts a pleiotropic immunomodulatory and antioxidant effect by shifting the balance from pro- to an antiinflammatory cytokine environment. This counteracts the effects of UV-induced cellular damage characteristic of photodermatoses.
光化性痒疹是一种罕见的瘙痒性光皮病。我们报告了一例白首乌提取物在 11 岁女性光化性痒疹患者中的应用，结果表明，在没有出现不良反应的情况下，她的疾病显著减轻。白首乌通过将平衡从促炎细胞因子环境转移到抗炎细胞因子环境，发挥多效性免疫调节和抗氧化作用。这可以抵抗光皮病特有的 UV 诱导的细胞损伤。
