Parrado Concepcion, Mascaraque Marta, Gilaberte Yolanda, Juarranz Angeles, Gonzalez Salvador
Pathology Department, School of Medicine, Universidad de Málaga, Malaga 29071, Spain.
Biology Department, Sciences School, Universidad Autónoma de Madrid, Madrid 28049, Spain.
Int J Mol Sci. 2016 Jun 29;17(7):1026. doi: 10.3390/ijms17071026.
Healthier life styles include increased outdoors time practicing sports and walking. This means increased exposure to the sun, leading to higher risk of sunburn, photoaging and skin cancer. In addition to topical barrier products, oral supplementations of various botanicals endowed with antioxidant activity are emerging as novel method of photoprotection. Polypodium leucotomos extract (PL, commercial name Fernblock(®), IFC Group, Spain) is a powerful antioxidant due to its high content of phenolic compounds. PL is administered orally, with proven safety, and it can also be used topically. Its mechanisms include inhibition of the generation and release of reactive oxygen species (ROS) by ultraviolet (UV) light. It also prevents UV- and ROS-induced DNA damage with inhibition of AP1 and NF-κB and protection of natural antioxidant enzyme systems. At the cellular level, PL decreases cellular apoptosis and necrosis mediated UV and inhibits abnormal extracellular matrix remodeling. PL reduces inflammation, prevents immunosuppression, activates tumor suppressor p53 and inhibits UV-induced cyclooxygenase-2 (COX-2) enzyme expression. In agreement with increased p53 activity, PL decreased UV radiation-induced cell proliferation. PL also prevents common deletions mitochondrial DNA damage induced by UVA, and MMP-1 expression induced Visible Light and Infrared Radiation. These cellular and molecular effects are reflected in inhibitions of carcinogenesis and photoaging.
更健康的生活方式包括增加户外活动时间，进行体育锻炼和散步。这意味着增加了阳光照射时间，从而导致晒伤、光老化和皮肤癌的风险增加。除了外用防护产品外，口服各种具有抗氧化活性的植物提取物正成为一种新的光防护方法。白叶铁线蕨提取物（PL，商品名Fernblock(®)，IFC集团，西班牙）由于其高含量的酚类化合物而具有强大的抗氧化作用。PL可口服，安全性已得到证实，也可外用。其作用机制包括抑制紫外线（UV）诱导的活性氧（ROS）的产生和释放。它还通过抑制AP1和NF-κB以及保护天然抗氧化酶系统来防止紫外线和ROS诱导的DNA损伤。在细胞水平上，PL减少紫外线介导的细胞凋亡和坏死，并抑制异常的细胞外基质重塑。PL减轻炎症，防止免疫抑制，激活肿瘤抑制因子p53，并抑制紫外线诱导的环氧合酶-2（COX-2）酶表达。与p53活性增加一致，PL降低了紫外线辐射诱导的细胞增殖。PL还可防止UVA诱导的线粒体DNA常见缺失损伤以及可见光和红外线辐射诱导的基质金属蛋白酶-1（MMP-1）表达。这些细胞和分子效应体现在对致癌作用和光老化的抑制上。
