Ningxia Medical University, Yinchuan, Ningxia, China.
Department of Orthopedics, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, China.
Medicine (Baltimore). 2021 Dec 10;100(49):e28085. doi: 10.1097/MD.0000000000028085.
Lumbar interbody fusion (LIF) is an effective treatment for lumbar degenerative diseases. Cage subsidence (CS) contitutes one of the most common postoperative complications. Many risk factors for CS after LIF have been reported in some studies. However, controversies still exist. The objective of this study will be to summarize data on the prevalence and risk factors of CS after LIF.
Our study present a protocol that conducted a systematic review and meta-analysis of prevalence and risk factors for CS after LIF. Two reviewers retrieved the relevant articles using the 5 databases (PubMed, Scopus, EMBASE, Cochrane Library, and Web of Science) from inception to May 31st, 2021. Primary outcome will be the prevalence of CS after LIF. Second outcomes include the risk factors associated with postoperative CS and clinical outcomes associated with postoperative CS. Three reviewers will screen citation titles and abstracts and evaluated full-text of each potentially relevant citation, and then extracted the data using a data extraction form. Any discrepancies in decisions between reviewers will be resolved through discussion. We assessed the methodological quality and risk of bias of the included studies based on the Newcastle-Ottawa Quality Assessment Scale (NOS). The aim of the extra analysis is to explore the explanations of the heterogeneity (age, gender, race, year of publication, type of study and surgical procedure). Publication bias will be assessed by Begg test, Egger test and funnel plots.
No primary data will be collected and individual patient information and endangering participant rights, thus ethics approval is not required. Findings will be reported through publication and media.
PROSPERO CRD42021257981 (https://www.crd.york.ac.uk/PROSPERO/#joinuppage).
腰椎体间融合术（LIF）是治疗腰椎退行性疾病的有效方法。 cage 沉降（CS）是最常见的术后并发症之一。一些研究报道了 LIF 后 CS 的许多危险因素。然而，仍存在争议。本研究的目的是总结 LIF 后 CS 的发生率和危险因素的数据。
我们的研究方案对 LIF 后 CS 的发生率和危险因素进行了系统评价和荟萃分析。两名审查员使用 5 个数据库（PubMed、Scopus、EMBASE、Cochrane Library 和 Web of Science）从成立到 2021 年 5 月 31 日检索相关文章。主要结局将是 LIF 后 CS 的发生率。次要结局包括与术后 CS 相关的危险因素和与术后 CS 相关的临床结局。三名审查员将筛选引用标题和摘要，并评估每篇潜在相关引用的全文，然后使用数据提取表提取数据。如果审查员之间存在分歧，则通过讨论解决。我们根据 Newcastle-Ottawa 质量评估量表（NOS）评估纳入研究的方法学质量和偏倚风险。额外分析的目的是探索（年龄、性别、种族、发表年份、研究类型和手术程序）异质性的解释。通过 Begg 检验、Egger 检验和漏斗图评估发表偏倚。
不会收集原始数据，也不会涉及个体患者信息和危害参与者权利，因此不需要伦理批准。研究结果将通过发表和媒体报告。
PROSPERO CRD42021257981（https://www.crd.york.ac.uk/PROSPERO/#joinuppage）。
