Yunnan University of Chinese Medicine, Kunming, China.
The First Affiliated Hospital of Yunnan University of Chinese Medicine, Kunming, China.
Medicine (Baltimore). 2021 Dec 10;100(49):e28163. doi: 10.1097/MD.0000000000028163.
Chronic prostatitis (CP) is a common disease in the outpatient department of males and urology. Clinical studies have found that acupuncture combined with traditional Chinese medicine (TCM) has achieved good results in treating CP, but its efficacy and safety are not completely clear. This study aimed to investigate the efficacy and safety of acupuncture combined with TCM in the treatment of CP.
Randomized controlled trials of acupuncture combined with TCM in treating CP were screened by searching PubMed, Embase, Cochrane Library, CNKI, etc. The retrieval time was from the database establishment date to March 31, 2021. The Cochrane Collaborative Risk Bias Assessment tool was used to evaluate literature's methodological quality of the literature. The RevMan5.4 software was used for the meta-analysis of outcome indicators. The TSA v0.9 software was used for sequential trial analysis (TSA) of effectiveness.
In this study, 19 related randomized controlled trial studies were included, with a total of 1831 cases. The results of the meta-analysis showed that acupuncture combined with TCM could significantly improve the clinical efficacy of CP (OR = 3.76, 95%CI: 2.82 to 5.02, P < .00001), reduce the total score of The National Institutes of Health chronic prostatitis symptom index (MD = -4.00, 95%CI: -4.67 to 3.33, P < .00001), and improve patients' urination symptoms (MD = -1.10, 95%CI: -1.23 to -0.97, P < .00001), alleviated the pain symptoms of patients (MD = -2.38, 95%CI: -2.41 to -2.35, P < .00001), improved the quality of life of patients (MD = -1.69, 95%CI: -1.97 to -1.41, P < .00001), decreased the scores of TCM symptoms of patients (MD = -2.39, 95%CI: -3.45 to -1.33, P < .00001), and did not increase the adverse reactions of patients (MD = 1.09, 95%CI: 0.57 to 2.06, P = .8). The results of publication bias showed that this study was not affected by publication bias, and the conclusion was reliable. TSA showed that acupuncture combined with TCM was effective in treating CP.
Acupuncture combined with TCM is safe and effective for alleviating CP. It can be used as an effective treatment for chronic prostatitis in the clinic.Registration number: DOI 10.17605/OSF.IO/Z8FJM.
慢性前列腺炎（CP）是男性泌尿科门诊的常见病。临床研究发现，针灸结合中医药治疗 CP 取得了较好的效果，但疗效和安全性尚不完全明确。本研究旨在探讨针灸结合中医药治疗 CP 的疗效和安全性。
通过检索 PubMed、Embase、Cochrane Library、CNKI 等数据库，筛选针灸结合中医药治疗 CP 的随机对照试验。检索时间从数据库建立日期至 2021 年 3 月 31 日。采用 Cochrane 协作偏倚风险评估工具评价文献的方法学质量。采用 RevMan5.4 软件进行结局指标的 meta 分析。采用 TSA v0.9 软件进行有效性的序贯试验分析（TSA）。
本研究共纳入 19 项相关的随机对照试验研究，共 1831 例患者。meta 分析结果显示，针灸结合中医药能显著提高 CP 的临床疗效（OR=3.76，95%CI：2.82 至 5.02，P<0.00001），降低 NIH 慢性前列腺炎症状指数总分（MD=-4.00，95%CI：-4.67 至 3.33，P<0.00001），改善患者排尿症状（MD=-1.10，95%CI：-1.23 至-0.97，P<0.00001），缓解患者疼痛症状（MD=-2.38，95%CI：-2.41 至-2.35，P<0.00001），提高患者生活质量（MD=-1.69，95%CI：-1.97 至-1.41，P<0.00001），降低患者中医症状评分（MD=-2.39，95%CI：-3.45 至-1.33，P<0.00001），且不增加患者不良反应（MD=1.09，95%CI：0.57 至 2.06，P=0.8）。发表偏倚结果显示，本研究不受发表偏倚影响，结论可靠。TSA 显示针灸结合中医药治疗 CP 有效。
针灸结合中医药治疗 CP 安全有效，可作为临床治疗慢性前列腺炎的有效方法。注册号：DOI 10.17605/OSF.IO/Z8FJM。
