Laboratorio "Dr. Fernando Cañas", Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
Facultad de Ciencias Médicas, UNR, Rosario, Argentina.
Appl Physiol Nutr Metab. 2022 Apr;47(4):395-404. doi: 10.1139/apnm-2021-0473. Epub 2021 Dec 10.
We analyzed the effect of naringin (NAR), a flavonoid from citric fruits, on bone quality and biomechanical properties, as well as the redox state of bone marrow in rats fed a fructose-rich diet (FRD), an experimental model to mimic human metabolic syndrome. NAR blocked the increase in the number of osteoclasts and adipocytes and the decrease in the number of osteocytes and osteocalcin (+) cells caused by FRD. Trabecular number was significantly higher in the FRD+NAR group. FRD induced a decrease in the femoral trabecular and cortical bone mineral density, which was blocked by NAR. The fracture and ultimate loads were also decreased in the FRD and FRD+NAR groups. NAR increased the number of nodes to terminal trabecula, the number of nodes to node trabecula, the number of nodes, and the number of nodes with 2 terminals and decreased the Dist (mean size of branches) value. FRD decreased bone marrow catalase activity, an effect that was prevented by NAR. In conclusion, FRD has detrimental effects on the long bones, which are associated with oxidative stress in the bone marrow. Most of these changes are prevented by NAR through its antioxidant properties and promotion of bone formation. Fructose-rich diets have detrimental effects on long bones, which are associated with oxidative stress in the bone marrow. Most of these changes are prevented by naringin through its antioxidant properties and promotion of bone formation.
我们分析了柚皮苷（NAR）对骨质量和生物力学特性以及富果糖饮食（FRD）喂养大鼠骨髓氧化还原状态的影响，FRD 是一种模拟人类代谢综合征的实验模型。NAR 阻止了 FRD 引起的破骨细胞和脂肪细胞数量增加以及成骨细胞和骨钙素（+）细胞数量减少。FRD+NAR 组的小梁数量明显更高。FRD 导致股骨小梁和皮质骨骨密度降低，NAR 可阻止这种降低。FRD 和 FRD+NAR 组的骨折和极限负荷也降低。NAR 增加了终末小梁的节点数、节点小梁的节点数、节点数和具有 2 个末端的节点数，并降低了 Dist（分支平均大小）值。FRD 降低了骨髓过氧化氢酶活性，NAR 可防止这种降低。总之，FRD 对长骨有不良影响，这与骨髓中的氧化应激有关。NAR 通过其抗氧化特性和促进骨形成来预防大多数这些变化。富果糖饮食对长骨有不良影响，这与骨髓中的氧化应激有关。NAR 通过其抗氧化特性和促进骨形成来预防大多数这些变化。
