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MPTP 毒性:临床特征

MPTP toxicity: clinical features.

作者信息

Williams A

出版信息

J Neural Transm Suppl. 1986;20:5-9.

PMID:3489070
Abstract

MPTP causes acute irreversible Parkinsonism in man that mimics the idiopathic condition exactly. It is therefore a better model of the naturally occurring disease than previously described cases secondary to other chemicals or viruses.

摘要

MPTP可导致人类急性不可逆性帕金森症,与特发性帕金森症完全相似。因此,相较于先前描述的继发于其他化学物质或病毒的病例,它是自然发生疾病的更好模型。

相似文献

1
MPTP toxicity: clinical features.MPTP 毒性:临床特征
J Neural Transm Suppl. 1986;20:5-9.
2
Effect of increasing regimens of levodopa on chronic MPTP-induced parkinsonism in monkey; mechanographic and electromyographic data.
Electromyogr Clin Neurophysiol. 1986 Dec;26(8):711-27.
3
Saccade responses to dopamine in human MPTP-induced parkinsonism.人类MPTP诱导的帕金森病中对多巴胺的扫视反应。
Ann Neurol. 1986 Oct;20(4):456-63. doi: 10.1002/ana.410200404.
4
MPTP and the aetiology of Parkinson's disease. Clinical implications. London, June 27, 1985.
J Neural Transm Suppl. 1986;20:1-81.
5
MPTP: a pharmacological tool to study parkinsonism.MPTP:一种用于研究帕金森病的药理学工具。
Methods Find Exp Clin Pharmacol. 1986 Aug;8(8):485-9.
6
MPTP-induced parkinsonism. Recent studies on the mechanism of toxicity.MPTP 诱导的帕金森症。毒性机制的最新研究。
Funct Neurol. 1988 Oct-Dec;3(4):439-47.
7
[Experimental model of Parkinson disease induced by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)].[由N-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)诱导的帕金森病实验模型]
Neuropatol Pol. 1986;24(1):1-8.
8
Deficits in behavioral initiation and execution processes in monkeys with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.1-甲基-4-苯基-1,2,3,6-四氢吡啶诱导的帕金森病猕猴行为启动和执行过程的缺陷
Neurosci Lett. 1985 Aug 30;59(2):225-32. doi: 10.1016/0304-3940(85)90204-6.
9
[Mechanism of induction of parkinsonism by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a dopaminergic neurotoxin].[1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP),一种多巴胺能神经毒素诱发帕金森症的机制]
Tanpakushitsu Kakusan Koso. 1986 Apr;31(5):398-409.
10
[Parkinsonism and MPTP (methylphenyltetrahydropyridine)].[帕金森综合征与MPTP(甲基苯基四氢吡啶)]
No To Shinkei. 1986 Jul;38(7):706-7.

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Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity.星形胶质细胞保护多巴胺能神经元免受氨基色素神经毒性的影响。
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Front Neurosci. 2019 Mar 29;13:271. doi: 10.3389/fnins.2019.00271. eCollection 2019.
6
Can we conclude a potential therapeutic action for Parkinson's disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?我们能否通过使用尸检组织和基于外源性神经毒素的临床前模型得出帕金森病的潜在治疗作用?
Cell Death Dis. 2018 Jul 3;9(7):748. doi: 10.1038/s41419-018-0798-0.
7
Neurotoxins as Preclinical Models for Parkinson's Disease.神经毒素作为帕金森病的临床前模型。
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Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update.与帕金森病相关的神经毒素机制及过程:最新进展
Neurotox Res. 2015 Apr;27(3):328-54. doi: 10.1007/s12640-015-9519-y. Epub 2015 Jan 29.