Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Traditional Medicine School, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mitochondrion. 2022 Jan;62:151-158. doi: 10.1016/j.mito.2021.12.001. Epub 2021 Dec 7.
Immunotherapy based on programmed cell death protein-1 (PD-1) is a promising approach in oncology. However, a significant fraction of patients remain unresponsive. Therefore, it is imperative to clarify the relevant predictive factors. A decrease in cellular adenosine triphosphate (c-ATP) level can predispose to cellular dysfunction. ATP is a prerequisite for proper T cell migration and activation. Therefore, a decrease in the c-ATP level impairs T cell function and promotes cancer progression. This article gives an overview of the potential predictive factors of PD-1 blockade. Besides, it highlights the pivotal role of mitochondria in response to anti-PD-1 therapies.
基于程序性死亡蛋白-1（PD-1）的免疫疗法是肿瘤学中一种很有前途的方法。然而，相当一部分患者仍然没有反应。因此，阐明相关的预测因素至关重要。细胞三磷酸腺苷（c-ATP）水平的降低可导致细胞功能障碍。ATP 是 T 细胞迁移和激活的必要条件。因此，c-ATP 水平的降低会损害 T 细胞功能并促进癌症进展。本文概述了 PD-1 阻断的潜在预测因素。此外，还强调了线粒体在抗 PD-1 治疗中的关键作用。
