Trasarti Stefania, Troiano Raffaele, Biglietto Mario, Sorella Silvia, Lisi Chiara, Assanto Giovanni Manfredi, Bizzoni Luisa, Brunetti Gregorio Antonio, Giordano Carla, Rullo Emma, Saracino Mariangela, Saullo Paolina, Vignetti Marco, Martelli Maurizio, Caronna Roberto
Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Department of Surgical Science, Sapienza University of Rome, 00161 Rome, Italy.
J Clin Med. 2022 Nov 26;11(23):6979. doi: 10.3390/jcm11236979.
Since December 2019, the world has experienced a pandemic caused by SARS-CoV-2, a virus which spread throughout the world. Anti-COVID19 measures were applied to limit the spread of the infection, affecting normal clinical practice. In 2020, studies on the possible impact of the pandemic considering the screening programs for early diagnosis of cancer were conducted, resulting in a prediction of delayed diagnosis of cancer. We performed a retrospective monocentric study on patients who present with the onset of lymphadenomegalies evaluated at our Hematological Department from February 2019 to October 2021 and undergoing excisional lymph-node biopsy. Three periods were considered: pre-pandemic, first pandemic period and second pandemic period (Group A, B and C). We included 258 patients who underwent a surgical biopsy and received a histological diagnosis. Hematological evaluation of outpatients sent by the general practitioner and surgical biopsies did not decrease among the three groups, despite limitations placed during this pandemic as well as new diagnoses of hematological malignancies. However, the diagnosis of metastatic cancer significantly increased from 2019 (7.8%) to 2021 (22.1%) ( = 0.042). Our data supports the hypothesis that the pandemic affected the national screening programs of early cancer detection.
自2019年12月以来，全球经历了由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的大流行，该病毒在全球范围内传播。为限制感染传播采取了抗击2019冠状病毒病的措施，这对正常临床实践产生了影响。2020年，开展了关于大流行对癌症早期诊断筛查项目可能影响的研究，结果预测癌症诊断会延迟。我们对2019年2月至2021年10月在我院血液科接受评估并进行淋巴结切除活检的淋巴结肿大初发患者进行了一项回顾性单中心研究。研究考虑了三个时期：大流行前、大流行第一时期和大流行第二时期（A组、B组和C组）。我们纳入了258例行手术活检并获得组织学诊断的患者。尽管在此次大流行期间存在限制因素以及血液系统恶性肿瘤有新的诊断病例，但三组中由全科医生转诊的门诊患者的血液学评估和手术活检数量并未减少。然而，转移性癌症的诊断从2019年的7.8%显著增至2021年的22.1%（ = 0.042）。我们的数据支持了大流行影响国家早期癌症检测筛查项目这一假说。
