Faculty of Sport, University of Ljubljana, Ljubljana, Slovenia; Department of Automation, Biocybernetics and Robotics, Jozef Stefan Institute, Ljubljana, Slovenia.
Department of Pulmonary Function Testing and Exercise Physiology, CHRU de Nancy, Nancy, France; Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Respir Physiol Neurobiol. 2022 Mar;297:103828. doi: 10.1016/j.resp.2021.103828. Epub 2021 Dec 7.
We aimed to gauge the interstitial lung water accumulation following moderate-intensity exercise under normobaric and hypobaric hypoxic conditions in a group of preterm born but otherwise healthy young adults. Sixteen pre-term-born individuals (age = 21±2yrs.; gestational age = 29±3wk.; birth weight = 1160±273 g) underwent two 8 -h hypoxic/altitude exposures in a cross-over manner: 1) Normobaric hypoxic exposure (NH; FO = 0.142±0.001; PO = 90.6±0.9 mmHg) 2) Hypobaric hypoxic exposure (HH; terrestrial high-altitude 3840 m; PO = 90.2±0.5 mmHg). Interstitial lung water was assessed via quantification of B-Lines (using lung ultrasound) before (normoxia) and after 4-h and 8-h of respective exposures. At each time point, B-Lines were quantified before (Pre) and immediately after (Post) a 6-min moderate-intensity exercise. The baseline B-lines count were comparable between both conditions (P = 0.191). A higher B-lines count was noted at Pre-H4 in HH versus NH (P = 0.0420). At Post-H8 B-lines score was significantly higher in HH (4.6 ± 1.6) than in NH (3.1 ± 1.4; P = 0.0073). Furthermore, at this time point, a significantly higher number of individuals with B-line scores ≥5 was observed in HH (n = 7) than in NH (n = 3; P = 0.0420). These findings suggest that short moderate-intensity exercise provokes a significant increase in the interstitial lung water accumulation after 8 h of exposure to terrestrial but not simulated altitude (≈3840 m) in prematurely born adults. Further work is needed to elucidate the exact mechanisms of (moderate-intensity) exercise-induced interstitial lung water accumulation in this population and directly compare the obtained data to full-term born adults.
我们旨在评估一组早产儿但其他方面健康的年轻成年人在常压和低压缺氧条件下进行中等强度运动后间质肺水的积累情况。16 名早产儿（年龄=21±2 岁；胎龄=29±3 周；出生体重=1160±273g）以交叉方式进行了两次 8 小时的缺氧/海拔暴露：1）常压缺氧暴露（NH；FO=0.142±0.001；PO=90.6±0.9mmHg）2）低压缺氧暴露（HH；陆地高海拔 3840m；PO=90.2±0.5mmHg）。间质肺水通过定量 B 线（使用肺部超声）来评估，分别在暴露前（常氧）和暴露后 4 小时和 8 小时进行。在每个时间点，在进行 6 分钟中等强度运动之前（Pre）和之后（Post）立即对 B 线进行定量。两种情况下的基线 B 线计数无差异（P=0.191）。在 HH 中，在 Pre-H4 时观察到更高的 B 线计数（P=0.0420）。在 Post-H8 时，HH 的 B 线评分明显高于 NH（4.6±1.6 比 3.1±1.4；P=0.0073）。此外，在此时点，HH 中有更多的个体 B 线评分≥5（n=7）比 NH（n=3；P=0.0420）。这些发现表明，在早产成年人中，与模拟海拔（≈3840m）相比，短时间的中等强度运动后，在暴露于陆地 8 小时后会引起间质肺水的显著增加。需要进一步的工作来阐明（中等强度）运动引起的间质肺水在该人群中的积累的确切机制，并直接将获得的数据与足月出生的成年人进行比较。
