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不稳定热与青蛙肌肉松弛速率的变化

Labile heat and changes in rate of relaxation of frog muscles.

作者信息

Peckham M, Woledge R C

出版信息

J Physiol. 1986 May;374:123-35. doi: 10.1113/jphysiol.1986.sp016070.

Abstract

Observations were made of the labile heat and the progressive slowing of relaxation as a function of tetanus duration (Abbott effect) during isometric tetani of frog extensor longus digiti IV (e.l.d. iv) and sartorius muscle. Both the labile heat and slowing of relaxation are less marked in e.l.d. iv than in sartorius muscle. Both effects are depressed to the same extent in the second of two closely spaced tetani in sartorius muscle. The repriming of both effects follows the same time course in sartorius muscle. The hypothesis is discussed that both effects result from binding of calcium to parvalbumin during a tetanus, and that their repriming is due to the removal of calcium from parvalbumin by the sarcoplasmic reticulum.

摘要

在青蛙第四趾长伸肌(e.l.d. iv)和缝匠肌的等长强直收缩过程中,观察了不稳定热以及作为强直收缩持续时间函数的舒张逐渐减慢(阿博特效应)。不稳定热和舒张减慢在e.l.d. iv中比在缝匠肌中表现得更不明显。在缝匠肌中两个紧密间隔的强直收缩的第二个中,这两种效应都被同等程度地抑制。这两种效应的再激发在缝匠肌中遵循相同的时间进程。讨论了这样一种假说,即这两种效应都是由于强直收缩期间钙与小清蛋白结合所致,而它们的再激发是由于肌浆网将钙从小清蛋白中移除。

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