Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Pôle de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Pôle de Psychiatrie, Centre Hospitalier Régional Universitaire de Strasbourg, Strasbourg, France; Université de Lorraine, Vandœuvre-lès-Nancy, France.
Schizophr Res. 2022 Jan;239:134-141. doi: 10.1016/j.schres.2021.11.049. Epub 2021 Dec 7.
Retinal dysfunction is widely documented in schizophrenia using flash (fERG) and pattern electroretinograms (PERG), but the role of dopamine transmission has seldom been explored.
We explored the role of dopamine transmission by evaluating the spatial location of retinal anomalies using multifocal ERG (mfERG) in photopic condition and the oscillatory potentials (OPs) extracted from fERG measured in scotopic condition in 29 patients with schizophrenia and 29 healthy controls.
With the mfERG, our main results revealed reduced amplitudes in the center of the retina: P1 (p < .005) and N2 amplitudes (p < .01) in the <2° region, N1 (p < .0005) and P1 amplitudes (p < .001) in the 2-5° region and P1 amplitude (p < .05) in the 5-10° region. For OPs, our results showed a decrease in the O1 (p < .005), O2 (p < .005), O3 (p < .05) and overall O1, O2, O3 index amplitudes (p < .005) in patients with schizophrenia.
Both the central location of retinal dysfunctions of the mfERG and OPs results could reflect a hypodopaminergic effect in patients with schizophrenia. In future studies, OPs should be considered as a measure to evaluate the hypodopaminergy in patients.
使用闪光视网膜电图（fERG）和图形视网膜电图（PERG）广泛记录到精神分裂症中的视网膜功能障碍，但多巴胺传递的作用很少被探索。
我们通过评估明适应多焦视网膜电图（mfERG）中视网膜异常的空间位置和暗适应 fERG 中提取的振荡电位（OPs），来探究多巴胺传递的作用，共纳入 29 名精神分裂症患者和 29 名健康对照者。
通过 mfERG，我们的主要结果显示中心视网膜的振幅降低：<2°区域的 P1（p<.005）和 N2 振幅（p<.01）、2-5°区域的 N1（p<.0005）和 P1 振幅（p<.001）以及 5-10°区域的 P1 振幅（p<.05）。对于 OPs，我们的结果显示精神分裂症患者的 O1（p<.005）、O2（p<.005）、O3（p<.05）和整体 O1、O2、O3 指数振幅降低（p<.005）。
mfERG 的中央视网膜功能障碍和 OPs 结果均反映出精神分裂症患者的多巴胺能低下。在未来的研究中，OPs 应被视为评估患者多巴胺能低下的一种测量手段。
