Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France; Faculté de Médecine, Université de Lorraine, Vandœuvre-lès-Nancy, France.
Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, France.
J Psychiatr Res. 2024 Feb;170:348-354. doi: 10.1016/j.jpsychires.2023.12.034. Epub 2023 Dec 24.
Alcohol is the most widely consumed addictive substance around the world and have deleterious effect on the central nervous system. Alcohol consumption affect the balance of certain neurotransmitters like GABA, glutamate and dopamine. The retina provides an easy means of investigating dysfunctions of synaptic transmission in the brain. The purpose of this study is to assess the impact of alcohol consumption on retinal function using pattern electroretinogram (PERG) and flash electroretinogram (fERG).
We recorded PERG and fERG under scotopic and photopic condition in 20 patients with alcohol use disorder and 20 controls. Implicit time and amplitude of numerous parameters were evaluated: a- and b-waves for fERG, OP3 and OP4 for dark-adapted 3.0 oscillatory potentials fERG, P50 and N95 for PERG.
Patients with alcohol use disorder showed a significant increase in N95 implicit time without a significant change in the amplitudes of oscillatory potentials.
The results of our study reflect the impact of alcohol use on ganglion cell function and could highlight alterations in glutamatergic neurotransmission inside the retina. We believe that ERG could be used as an early marker of alcohol consumption.
酒精是世界上使用最广泛的成瘾物质，对中枢神经系统有有害影响。酒精的摄入会影响 GABA、谷氨酸和多巴胺等特定神经递质的平衡。视网膜为研究大脑中突触传递功能障碍提供了一种简单的方法。本研究旨在使用图形视网膜电图（PERG）和闪光视网膜电图（fERG）评估酒精摄入对视网膜功能的影响。
我们在 20 名酒精使用障碍患者和 20 名对照者中记录了暗适应和明适应条件下的 PERG 和 fERG。评估了许多参数的潜伏期和振幅：fERG 的 a 和 b 波，暗适应 3.0 微振电位 fERG 的 OP3 和 OP4，PERG 的 P50 和 N95。
酒精使用障碍患者的 N95 潜伏期显著增加，而微振电位的振幅没有显著变化。
我们研究的结果反映了酒精使用对节细胞功能的影响，并可能突出了视网膜内谷氨酸能神经传递的改变。我们认为 ERG 可以作为酒精摄入的早期标志物。
