Kazimierska Agnieszka, Uryga Agnieszka, Mataczynski Cyprian, Burzynska Malgorzata, Ziolkowski Arkadiusz, Rusiecki Andrzej, Kasprowicz Magdalena
Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:546-549. doi: 10.1109/EMBC46164.2021.9630516.
Intracranial pressure (ICP) pulse waveform, i.e., the shape of the ICP signal over a single cardiac cycle, is regarded as a potential source of information about intracranial compliance. In this study we aimed to compare the results of automatic classification of ICP pulse shapes on a scale from normal to pathological with other ICP pulse-derived metrics. Additionally, identification of artifacts was performed simultaneously with pulse classification to assess the effect of artifact removal on the results. Data from 35 traumatic brain injury (TBI) patients were analyzed retrospectively in terms of dominant waveform shape, mean ICP, mean amplitude of ICP (AmpICP), mean index of compensatory reserve (RAP index), and their association with the patient's clinical outcome. Our results show that patients with poor outcome exhibit more pathological waveform shape than patients with good outcome. More pathological ICP pulse shape is associated with higher mean ICP, mean AmpICP, and RAP.Clinical relevance- In the clinical setting, ICP pulse waveform analysis could potentially be used to complement the commonly monitored mean ICP and improve the assessment of intracranial compliance in TBI patients. Artifact removal from the ICP signal could reduce the frequency of false positive detection of clinically adverse events.
颅内压（ICP）脉搏波形，即单个心动周期内ICP信号的形状，被视为颅内顺应性信息的潜在来源。在本研究中，我们旨在将ICP脉搏形状从正常到病理性的自动分类结果与其他源自ICP脉搏的指标进行比较。此外，在进行脉搏分类的同时进行伪迹识别，以评估去除伪迹对结果的影响。回顾性分析了35例创伤性脑损伤（TBI）患者的数据，包括主要波形形状、平均ICP、ICP平均振幅（AmpICP）、平均代偿储备指数（RAP指数），以及它们与患者临床结局的关联。我们的结果表明，预后不良的患者比预后良好的患者表现出更多的病理性波形形状。更多病理性的ICP脉搏形状与更高的平均ICP、平均AmpICP和RAP相关。临床意义——在临床环境中，ICP脉搏波形分析可能有助于补充常用的平均ICP监测，并改善对TBI患者颅内顺应性的评估。从ICP信号中去除伪迹可以减少临床不良事件假阳性检测的频率。
