Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:1072-1075. doi: 10.1109/EMBC46164.2021.9630946.
Intrapartum fetal well-being assessment relies on fetal heart rate (FHR) monitoring. Studies have shown that FHR monitoring has a high false-positive rate for detecting fetal hypoxia during labor and delivery. A transabdominal fetal pulse oximeter device that measures fetal oxygen saturation non-invasively through NIR light source and photodetectors could increase the accuracy of hypoxia detection. As light travels through both maternal and fetal tissue, photodetectors on the surface of mother's abdomen capture mixed signals comprising fetal and maternal information. The fetal information should be extracted first to enable fetal oxygen saturation calculation. A multi-detector fetal signal extraction method is presented in this paper where adaptive noise cancellation is applied to four mixed signals captured by four separate photodetectors placed at varying distances from the light source. As a result of adaptive noise cancellation, we obtain four separate FHR by peak detection. Weighting, outlier rejection and averaging are applied to these four fetal heart rates and a mean FHR is reported. The method is evaluated in utero on data collected from hypoxic lamb model. Ground truth for FHR is measured through hemodynamics. The results showed that using multi-detector fetal signal extraction gave up to 18.56% lower root-mean-square FHR error, and up to 57.87% lower maximum absolute FHR error compared to single-detector fetal signal extraction.
产时胎儿健康评估依赖于胎儿心率 (FHR) 监测。研究表明,FHR 监测在检测分娩过程中胎儿缺氧方面的假阳性率很高。一种通过近红外光源和光电探测器无创测量胎儿氧饱和度的经腹胎儿脉搏血氧仪设备可以提高缺氧检测的准确性。由于光通过母体和胎儿组织传播,母体腹部表面的光电探测器捕获包含胎儿和母体信息的混合信号。应该首先提取胎儿信息,以实现胎儿氧饱和度的计算。本文提出了一种多探测器胎儿信号提取方法,其中自适应噪声消除应用于从光源以不同距离放置的四个独立光电探测器捕获的四个混合信号。由于自适应噪声消除,我们通过峰值检测获得了四个独立的 FHR。对这些四个胎儿心率进行加权、异常值拒绝和平均处理,并报告平均 FHR。该方法在缺氧羔羊模型收集的数据中进行了宫内评估。FHR 的真实值通过血液动力学进行测量。结果表明,与单探测器胎儿信号提取相比,多探测器胎儿信号提取可将均方根 FHR 误差降低多达 18.56%,最大绝对 FHR 误差降低多达 57.87%。