Luttkus A, Fengler T W, Friedmann W, Dudenhausen J W
Department of Obstetrics, University Hospital Rudolf Virchow, Berlin, Germany.
Obstet Gynecol. 1995 Feb;85(2):183-6. doi: 10.1016/0029-7844(94)00353-F.
To compare spectrophotometric saturation values of fetal blood sampling to the saturation readings by pulse oximetry.
During a clinical trial, fetal oxygen saturation was monitored during labor by a fetal oxisensor and a fetal pulse oximeter. Fifty-one fetal scalp blood samples were assessed because of abnormal fetal heart rate (FHR) patterns. The pulse oximeter displayed only signal quality readings. The investigator had to perform adjustments if signal quality fell below 50%. After delivery, the saturation at the moment of fetal blood analysis could be read from a printout and compared to the saturation values of scalp blood sampling.
The share of usable signal time was 51% overall, but only 40% in the 20-minute period during fetal blood sampling. Comparison with the reference method resulted in a median deviation of 6% (tenth percentile -10%; 90th percentile 18%) for pulse oximetry. The correlation coefficient between saturation values by pulse oximetry and fetal scalp blood sampling was 0.67. The correlation coefficient with the partial pressure of oxygen and oxygen saturation by pulse oximetry was 0.61, whereas it was 0.88 between partial pressure and saturation from the spectrophotometric analysis of the scalp sample.
Fetal pulse oximetry corresponds satisfactorily to results from fetal blood analysis. Low invasiveness and continuous monitoring are the advantages of this method. At present, the available sensor generates only a limited amount of signal time. However, in combination with FHR monitoring, pulse oximetry promises greatly improved detection of fetal hypoxia.
比较分光光度法测定的胎儿血样饱和度值与脉搏血氧饱和度仪的饱和度读数。
在一项临床试验中，使用胎儿氧传感器和胎儿脉搏血氧饱和度仪在分娩期间监测胎儿血氧饱和度。因胎儿心率（FHR）模式异常评估了51份胎儿头皮血样。脉搏血氧饱和度仪仅显示信号质量读数。如果信号质量低于50%，研究人员必须进行调整。分娩后，可从打印件中读取胎儿血样分析时的饱和度，并与头皮血样的饱和度值进行比较。
总体可用信号时间占比为51%，但在采集胎儿血样的20分钟期间仅为40%。与参考方法相比，脉搏血氧饱和度法的中位数偏差为6%（第十百分位数为-10%；第九十百分位数为18%）。脉搏血氧饱和度法测定的饱和度值与胎儿头皮血样饱和度之间的相关系数为0.67。脉搏血氧饱和度法测定的氧分压与血氧饱和度之间的相关系数为0.61，而头皮样本分光光度分析的氧分压与饱和度之间的相关系数为0.88。
胎儿脉搏血氧饱和度法与胎儿血样分析结果相符性良好。该方法具有侵入性低和可连续监测的优点。目前，现有的传感器产生的信号时间有限。然而，与FHR监测相结合，脉搏血氧饱和度法有望大大提高胎儿缺氧的检测能力。
