Estimating Pulsatile Blood Flow Parameters from Digital Subtraction Angiography.

Digital subtraction angiography (DSA) is the gold standard for diagnosing vascular diseases. Much attention had been attracted on estimating blood flow velocity from DSA data, and many techniques to compute the mean flow velocity had been proposed. In this paper, we present a physical model that demonstrates how the pulsatile flow can affect the dispersion of the contrast medium delivered into the blood vessel. Using empirical mode decomposition and angiographic data of 4 patients, we then showed it is feasible to compute pulsatile flow related parameters from routine interventional angiographic acquisitions.Clinical Relevance- This is the first attempt to present a physical model and corresponding method to estimate pulsatile flow related parameters from routine angiographic acquisitions, and has potential to be used for real-time diagnostic and therapeutic monitoring during interventional procedures.