Annu Int Conf IEEE Eng Med Biol Soc. 2021 Nov;2021:4297-4302. doi: 10.1109/EMBC46164.2021.9629482.
A multi-physical model of a human urinary bladder is an essential element for the potential application of electrical impedance spectroscopy during transurethral resection surgery, where measurements are taken at different fill levels inside the bladder. This work derives a multi-physical bladder tissue model that incorporates the electrical impedance properties with dependence on mechanical deformation due to filling of the bladder. The volume and ratio of the intracellular to extracellular tissue fluid heavily influence the electrical impedance characteristics and thus provide the connection between the mechanical and electrical domains. Modeling the fluid within the tissue links both the physical and histological processes and enables useful inferences of the properties from empiric observations. This is demonstrated by taking impedance measurements at different fill volumes. The resulting model provides a tool to analyze impedance measurements during surgery at different stress levels. In addition, this model can be used to determine patient-specific tissue parameters.
人体膀胱的多物理模型是经尿道膀胱肿瘤切除术（transurethral resection surgery，TURs）中应用电阻抗谱术的潜在应用的基本要素，因为在 TURs 中会在膀胱内的不同填充水平进行测量。本工作推导了一个多物理膀胱组织模型，该模型将电阻抗特性与由于膀胱填充引起的机械变形的依赖性结合起来。细胞内组织液与细胞外组织液的体积比和比例对电阻抗特性有很大影响，从而为机械和电气领域之间提供了连接。对组织内液体进行建模可以将物理和组织学过程联系起来，并可以根据经验观察对特性进行有用的推断。通过在不同填充体积下进行阻抗测量来证明这一点。所得到的模型为在不同的压力水平下进行手术时分析阻抗测量提供了一种工具。此外，该模型还可用于确定特定于患者的组织参数。
