Ghanayem B I, Ahmed A E
Res Commun Chem Pathol Pharmacol. 1986 Jul;53(1):141-4.
We have recently demonstrated that acrylonitrile (VCN) causes acute gastric hemorrhage and mucosal erosions. The current studies were undertaken to investigate the effects of the sulfhydryl-containing compounds, cysteine and cysteamine, the cholinergic blocking agent atropine and the histamine H2 receptor antagonist, cimetidine on the VCN-induced gastrointestinal (GI) bleeding in rats. Our data shows that pretreatment with L-cysteine, cysteamine, atropine or cimetidine has significantly protected rats against the VCN-induced GI bleeding. A possible mechanism of the VCN-induced GI bleeding may involve the interaction of VCN with critical sulfhydryl groups that, in turn, causes alteration of acetylcholine muscarinic receptors to lead to gastric hemorrhagic lesions and bleeding.
我们最近证实，丙烯腈（VCN）会导致急性胃出血和黏膜糜烂。目前的研究旨在探讨含巯基化合物半胱氨酸和半胱胺、胆碱能阻滞剂阿托品以及组胺H2受体拮抗剂西咪替丁对VCN诱导的大鼠胃肠道（GI）出血的影响。我们的数据表明，用L-半胱氨酸、半胱胺、阿托品或西咪替丁预处理可显著保护大鼠免受VCN诱导的GI出血。VCN诱导GI出血的一种可能机制可能涉及VCN与关键巯基的相互作用，进而导致乙酰胆碱毒蕈碱受体改变，从而导致胃出血性病变和出血。
