壳聚糖纳米载药颗粒负载大蒜精油：作为种衣剂替代戊唑醇的新选择。
Chitosan nanoparticles loaded with garlic essential oil: A new alternative to tebuconazole as seed dressing agent.
机构信息
Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
Instituto Botánico, Departamento de Ciencia y Tecnología Agroforestal y Genética. Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain; Escuela Técnica Superior deIngenieros Agrónomos y Montes, Departamento de Ciencia y Tecnología Agroforestal y Genética, Universidad de Castilla-La Mancha, Campus Universitario s/n, 02071 Albacete, Spain.
出版信息
Carbohydr Polym. 2022 Feb 1;277:118815. doi: 10.1016/j.carbpol.2021.118815. Epub 2021 Oct 27.
In this study, garlic essential oil (GEO) has been encapsulated in chitosan nanoparticles (NPCH) with sodium tripolyphosphate (TPP). Fourier transform infrared (FT-IR) spectroscopy, UV-vis spectrophotometry, thermogravimetric analysis (TGA) and X-ray diffraction (XRD) techniques were applied to characterize GEO-NPCH. The obtained nanoparticles exhibited a regular distribution and spherical shape with size range of 200-400 nm as revealed by scanning electron microscopy (SEM). The maximum encapsulation efficiency (EE) and loading capacity (LC) of GEO-loaded chitosan nanoparticles were about 32.8% and 19.8% respectively. Nanoparticle formulations of GEO were found to have antifungal activity against Aspergillus versicolor, A. niger and Fusarium oxysporum. In addition, they showed growth promoting effects by increasing emergence, shoot and root fresh weight on wheat, oat and barley.
在这项研究中，大蒜精油（GEO）已被封装在壳聚糖纳米粒子（NPCH）中，同时使用三聚磷酸钠（TPP）作为交联剂。傅里叶变换红外（FT-IR）光谱、紫外-可见分光光度法、热重分析（TGA）和 X 射线衍射（XRD）技术被用于对 GEO-NPCH 进行表征。扫描电子显微镜（SEM）显示，所得到的纳米粒子呈规则分布且具有球形形状，粒径范围为 200-400nm。负载 GEO 的壳聚糖纳米粒子的最大包封效率（EE）和载药量（LC）分别约为 32.8%和 19.8%。发现 GEO 的纳米粒子制剂对土曲霉、黑曲霉和尖孢镰刀菌具有抗真菌活性。此外，它们通过增加小麦、燕麦和大麦的出苗、茎和根的鲜重表现出促进生长的作用。
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