• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis.

作者信息

Yang Li, Chen Jin, Liang Jianqing, Zhang Yufeng, Wang Qingzhe, Ren Xiaojun, Wei Jinsong, Gong Qianchun, Zhang Jiting, Jiang Ning, Lin Xinhua, Li Jin, Zhao Bing

机构信息

State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.

bioGenous Biotechnology, Inc., Hangzhou, 311231, China.

出版信息

Protein Cell. 2022 Sep;13(9):683-688. doi: 10.1007/s13238-021-00893-0. Epub 2021 Dec 10.

DOI:10.1007/s13238-021-00893-0
PMID:34893955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9233724/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c8/9233724/5617391ce000/13238_2021_893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c8/9233724/6ce19db31a06/13238_2021_893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c8/9233724/5617391ce000/13238_2021_893_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c8/9233724/6ce19db31a06/13238_2021_893_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5c8/9233724/5617391ce000/13238_2021_893_Fig2_HTML.jpg

相似文献

1
Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis.用人胎儿肝脏类器官模拟肝母细胞瘤的发展表明，YAP1激活足以引发肿瘤发生。
Protein Cell. 2022 Sep;13(9):683-688. doi: 10.1007/s13238-021-00893-0. Epub 2021 Dec 10.
2
Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.β-连环蛋白和 Yap1 在人肝癌中的激活及在小鼠中诱导肝癌发生。
Gastroenterology. 2014 Sep;147(3):690-701. doi: 10.1053/j.gastro.2014.05.004. Epub 2014 May 14.
3
YAP/TAZ Suppress Drug Penetration Into Hepatocellular Carcinoma Through Stromal Activation.YAP/TAZ通过基质激活抑制药物渗透进入肝细胞癌。
Hepatology. 2021 Nov;74(5):2605-2621. doi: 10.1002/hep.32000. Epub 2021 Aug 25.
4
A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing.用于疾病建模和药物测试的侵袭性肝母细胞瘤人源类器官模型
Cancers (Basel). 2020 Sep 18;12(9):2668. doi: 10.3390/cancers12092668.
5
Hippo/YAP, β-catenin, and the cancer cell: a "ménage à trois" in hepatoblastoma.河马通路/Yes相关蛋白、β-连环蛋白与癌细胞：肝母细胞瘤中的“三角关系”
Gastroenterology. 2014 Sep;147(3):562-5. doi: 10.1053/j.gastro.2014.07.026. Epub 2014 Jul 27.
6
ARID1A-mutated cervical cancer depends on the activation of YAP signaling.ARID1A 突变型宫颈癌依赖于 YAP 信号的激活。
Front Biosci (Landmark Ed). 2021 Dec 30;26(12):1411-1421. doi: 10.52586/5035.
7
Hepatoblastoma with cholangioblastic features ('cholangioblastic hepatoblastoma') and other liver tumors with bimodal differentiation in young patients.具有胆管母细胞特征的肝母细胞瘤（“胆管母细胞性肝母细胞瘤”）及年轻患者中具有双峰分化的其他肝脏肿瘤。
Med Pediatr Oncol. 2002 Nov;39(5):487-91. doi: 10.1002/mpo.10173.
8
GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling.Wnt 信号诱导 GREB1 的表达可通过抑制 TGFβ 信号促进肝母细胞瘤的发生。
Nat Commun. 2019 Aug 28;10(1):3882. doi: 10.1038/s41467-019-11533-x.
9
LATS2-mediated YAP1 phosphorylation is involved in HCC tumorigenesis.LATS2介导的YAP1磷酸化参与肝癌的肿瘤发生。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1690-7. eCollection 2015.
10
β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis.β-连环蛋白和 Yes 相关蛋白 1 在肝癌发病机制中协同作用。
Am J Pathol. 2019 May;189(5):1091-1104. doi: 10.1016/j.ajpath.2019.02.002. Epub 2019 Feb 19.

引用本文的文献

1
LncRNA938/ TAF9/TTK axis promotes EMT and serves as a therapeutic target in hepatoblastoma.长链非编码RNA938/TAF9/TTK轴促进上皮-间质转化并作为肝母细胞瘤的治疗靶点。
J Transl Med. 2025 Aug 21;23(1):946. doi: 10.1186/s12967-025-06809-4.
2
Biomedical applications of organoids derived from the digestive system.源自消化系统的类器官的生物医学应用。
Front Cell Dev Biol. 2025 May 30;13:1599384. doi: 10.3389/fcell.2025.1599384. eCollection 2025.
3
Primary liver cancer organoids and their application to research and therapy.原发性肝癌类器官及其在研究与治疗中的应用。

本文引用的文献

1
Molecular Mechanisms of Hepatoblastoma.肝癌的分子机制。
Semin Liver Dis. 2021 Jan;41(1):28-41. doi: 10.1055/s-0040-1722645. Epub 2021 Jan 20.
2
The Hippo Pathway in Liver Homeostasis and Pathophysiology.Hippo 通路在肝脏稳态和病理生理学中的作用。
Annu Rev Pathol. 2021 Jan 24;16:299-322. doi: 10.1146/annurev-pathol-030420-105050. Epub 2020 Nov 24.
3
How Do Synchronous Lung Metastases Influence the Surgical Management of Children with Hepatoblastoma? An Update and Systematic Review of the Literature.同步性肺转移如何影响肝母细胞瘤患儿的外科治疗？文献综述与最新进展
J Natl Cancer Cent. 2024 Jun 17;4(3):195-202. doi: 10.1016/j.jncc.2024.06.002. eCollection 2024 Sep.
4
Research progress on the application of organoids in gynecological tumors.类器官在妇科肿瘤中的应用研究进展
Front Pharmacol. 2024 Jun 26;15:1417576. doi: 10.3389/fphar.2024.1417576. eCollection 2024.
5
Liver organoids: a promising three-dimensional model for insights and innovations in tumor progression and precision medicine of liver cancer.肝类器官：肿瘤进展和肝癌精准医学中洞察和创新的有前途的三维模型。
Front Immunol. 2023 Jun 2;14:1180184. doi: 10.3389/fimmu.2023.1180184. eCollection 2023.
6
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma.肿瘤内红细胞岛抑制肝母细胞瘤中的抗肿瘤免疫。
Cell Rep Med. 2023 May 16;4(5):101044. doi: 10.1016/j.xcrm.2023.101044.
7
Human liver organoid: modeling liver steatosis and beyond.人肝脏类器官：模拟肝脂肪变性及其他情况。
Cell Regen. 2023 Apr 3;12(1):17. doi: 10.1186/s13619-023-00161-y.
8
Taurodeoxycholic acid-YAP1 upregulates OTX1 in promoting gallbladder cancer malignancy through IFITM3-dependent AKT activation.牛磺胆酸-YAP1 通过 IFITM3 依赖性 AKT 激活上调 OTX1 促进胆囊癌恶性进展。
Oncogene. 2023 May;42(18):1466-1477. doi: 10.1038/s41388-023-02660-3. Epub 2023 Mar 16.
9
A decade of liver organoids: Advances in disease modeling.肝类器官研究的十年进展：疾病建模的新突破
Clin Mol Hepatol. 2023 Jul;29(3):643-669. doi: 10.3350/cmh.2022.0428. Epub 2023 Mar 6.
10
EVlncRNA-Dpred: improved prediction of experimentally validated lncRNAs by deep learning.EVlncRNA-Dpred：通过深度学习提高实验验证的 lncRNA 预测。
Brief Bioinform. 2023 Jan 19;24(1). doi: 10.1093/bib/bbac583.
Cancers (Basel). 2019 Oct 31;11(11):1693. doi: 10.3390/cancers11111693.
4
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes.利用直接重编程的人源肝细胞衍生类器官建立肝癌起始模型。
Nat Cell Biol. 2019 Aug;21(8):1015-1026. doi: 10.1038/s41556-019-0359-5. Epub 2019 Jul 22.
5
Lgr5 stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool.Lgr5 干细胞和祖细胞位于异质性胚胎肝母细胞池的顶端。
Development. 2019 Jun 12;146(12):dev174557. doi: 10.1242/dev.174557.
6
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.三维类器官中功能性小鼠和人肝细胞的长期扩增。
Cell. 2018 Nov 29;175(6):1591-1606.e19. doi: 10.1016/j.cell.2018.11.013.
7
Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children's Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children's Oncology Group.儿童肿瘤学组AHEP0731方案（儿童各期肝母细胞瘤的治疗）治疗的肝母细胞瘤患儿肺转移特征：来自儿童肿瘤学组的报告
J Clin Oncol. 2017 Oct 20;35(30):3465-3473. doi: 10.1200/JCO.2017.73.5654. Epub 2017 Sep 11.
8
Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups.肝癌的基因组分析确定了不同的分子和预后亚组。
Hepatology. 2017 Jan;65(1):104-121. doi: 10.1002/hep.28888. Epub 2016 Nov 29.
9
Hippo/YAP, β-catenin, and the cancer cell: a "ménage à trois" in hepatoblastoma.河马通路/Yes相关蛋白、β-连环蛋白与癌细胞：肝母细胞瘤中的“三角关系”
Gastroenterology. 2014 Sep;147(3):562-5. doi: 10.1053/j.gastro.2014.07.026. Epub 2014 Jul 27.
10
Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.β-连环蛋白和 Yap1 在人肝癌中的激活及在小鼠中诱导肝癌发生。
Gastroenterology. 2014 Sep;147(3):690-701. doi: 10.1053/j.gastro.2014.05.004. Epub 2014 May 14.