Institute of Ecological Safety, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
Institute of Ecological Safety, Chongqing University of Posts and Telecommunications, Chongqing 400065, China.
Bioelectrochemistry. 2022 Apr;144:108029. doi: 10.1016/j.bioelechem.2021.108029. Epub 2021 Dec 2.
Electroporation occurs when biological cells are exposed to intensive, short-duration pulses, which can be used to ablate biological tumor tissues. Based on the traditional numerical models, the isotropic conductivity model with the non-dispersion effect (ICND), the anisotropic conductivity model with the dispersion effect (ACD) is developed in this study. The second-order Debye function is introduced to manifest the dielectric relaxation effect, and the two-dimensional Cartesian conductivity matrix is applied to describe the anisotropy of the tissue conductivity during the electroporation process. A monopolar pulse and a monopolar burst are applied to the breast tumor model through the two-needle electrodes configuration. The results show that taking the dispersion into account can increase the total electroporated area more than 2.31%. Considering the conductivity anisotropy, the total electroporated area increases, but the irreversible electroporation (IRE) area decreases by more than 3.99%. The ACD model can achieve a larger electroporated area but a relatively smaller IRE area than those of the ICND model, and comparably minor maximum thermal damage is evaluated in the ACD model. Our model analyzes the effects of the dielectric dispersion and anisotropic conductivity of tissue, which have strong guiding significance for making the treatment planning before clinical practice.
电穿孔发生在生物细胞暴露于高强度、短持续时间脉冲时，可以用于消融生物肿瘤组织。基于传统的数值模型，本研究开发了具有非弥散效应的各向同性电导率模型（ICND）和具有弥散效应的各向异性电导率模型（ACD）。二阶 Debye 函数用于体现介电弛豫效应，二维笛卡尔电导率矩阵用于描述电穿孔过程中组织电导率的各向异性。通过双针电极配置将单极脉冲和单极突发应用于乳腺肿瘤模型。结果表明，考虑弥散效应可以使总的电穿孔面积增加超过 2.31%。考虑到电导率各向异性，总的电穿孔面积增加，但不可逆电穿孔（IRE）面积减少超过 3.99%。ACD 模型可以实现比 ICND 模型更大的电穿孔面积，但相对较小的 IRE 面积，并且在 ACD 模型中评估的最大热损伤也较小。我们的模型分析了组织介电弥散和各向异性电导率的影响，这对临床实践前制定治疗计划具有很强的指导意义。
