Shen Zhang-Yang, Zhao Ying-Ying, Qiao Ze-Hua, Xie Zhen, Guan Ruo-Qing, Liu Ze-Yu, Liu Yan-Ping, Chen Guang-Ying, Fu Yan-Hui
Key Laboratory of Tropical Medicinal Resources Chemistry of Ministry of Education, Hainan Normal University, Haikou, P.R. China.
Key Laboratory of Research and Development of Tropical Fruit and Vegetable of Haikou City, Hainan Normal University, Haikou, P.R. China.
Nat Prod Res. 2023 May;37(9):1456-1462. doi: 10.1080/14786419.2021.2012670. Epub 2021 Dec 13.
The phytochemical investigation on the fruits of led to the isolation and characterization of a new anthraquinone, moricitrifone (), along with seven known anthraquinones (-). The chemical structure of was elucidated by extensive spectral analyses. The known compounds (-) were identified by comparing their spectral data with those reported in the literature. The antiproliferative activities of all isolated anthraquinones (-) against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 were evaluated . Compounds - exhibited remarkable antiproliferative activities with IC values ranging from 0.26 ± 0.05 to 16.58 ± 0.18 μM, which were comparable to those of doxorubicin.
对[植物名称]果实进行的植物化学研究,导致分离并鉴定出一种新的蒽醌,桑根三酮(),以及七种已知的蒽醌(-)。通过广泛的光谱分析阐明了的化学结构。通过将已知化合物(-)的光谱数据与文献报道的数据进行比较来鉴定它们。评估了所有分离出的蒽醌(-)对五种人类癌细胞系:HL-60、SMMC-7721、A-549、MCF-7和SW480的抗增殖活性。化合物-表现出显著的抗增殖活性,IC值范围为0.26±0.05至16.58±0.18μM,与阿霉素的活性相当。