Ee G C L, Wen Y P, Sukari M A, Go R, Lee H L
Department of Chemistry, Faculty of Science, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Nat Prod Res. 2009;23(14):1322-9. doi: 10.1080/14786410902753138.
An investigation of Morinda citrifolia roots afforded a new anthraquinone, 2-ethoxy-1-hydroxyanthraquinone (1), along with five other known anthraquinones: 1-hydroxy-2-methylanthraquinone (2), damnacanthal (3), nordamnacanthal (4), 2-formyl-1-hydroxyanthraquinone (5) and morindone-6-methyl-ether (6). This is the first report on the isolation of morindone-6-methyl-ether (6) from this plant. The structures of these compounds were elucidated based on spectroscopic analyses such as NMR, MS and IR. Biological evaluation of five pure compounds and all the extracts against the larvae of Aedes aegypti indicated 1-hydroxy-2-methylanthraquinone (2) and damnacanthal (3) were the extracts to exhibit promising larvicidal activities.
对巴戟天根进行的一项研究得到了一种新的蒽醌，即2-乙氧基-1-羟基蒽醌（1），以及其他五种已知的蒽醌：1-羟基-2-甲基蒽醌（2）、 damnacanthal（3）、去甲 damnacanthal（4）、2-甲酰基-1-羟基蒽醌（5）和巴戟醌-6-甲醚（6）。这是首次从该植物中分离出巴戟醌-6-甲醚（6）的报道。这些化合物的结构通过NMR、MS和IR等光谱分析得以阐明。对五种纯化合物和所有提取物针对埃及伊蚊幼虫的生物学评价表明，1-羟基-2-甲基蒽醌（2）和 damnacanthal（3）是具有良好杀幼虫活性的提取物。
