[Effect of microbial sensitization and delayed-type hypersensitivity reaction on interleukin-1 production and the generation of monocyte and natural killer cytotoxicity].

Injection of tuberculin PPD or BCG vaccine to tuberculin-positive (Tb+) healthy persons resulted in delayed-type hypersensitivity (DTH) reaction, and obvious monocyte and large granular lymphocyte (LGL) cytotoxicity activation, while the injection of the preparations to tuberculin-negative (Tb-) donors failed to influence the effector activity. Monocytes and LGL produced higher levels of interleukin-I (IL-I) in Tb+ than in Tb- persons. Blockade of Ia-structures with monoclonal antibodies or UV-radiation eliminated the stimulating effect of DTH reaction on monocyte and LGL cytotoxicity and IL-I production. The interaction with monocytes, possessing unaffected Ia-structures, is necessary for LGL activation in Tb+ persons treated with PPD.