Department of Psychiatry, Griffin Memorial Hospital, Norman, Oklahoma, USA.
School of Osteopathic Medicine, Arizona, A.T. Still University, Mesa, Arizona, USA.
Subst Use Misuse. 2022;57(3):344-349. doi: 10.1080/10826084.2021.2012690. Epub 2021 Dec 11.
To evaluate the odds for bipolar disorder (BP) mania and depression-related hospitalization due to cannabis use disorders (CUD).
We conducted a cross-sectional study using the national inpatient sample (NIS), and included adult BP hospitalizations sub-grouped by manic (N = 209,785) versus depressive episodes (N = 170480). A logistic regression model was used to evaluate adjusted odds ratio (aOR) of association between CUD and BP-mania-related hospitalizations and was adjusted for demographics confounders, psychiatric comorbidities and other substance use disorders (SUD).
Comorbidities were less prevalent in BP mania compared to BP depression: anxiety disorders (22.7% vs. 35.3%), PTSD (8.7% vs. 14.3%), and personality disorders (15.4% vs. 20.5%). Among SUD, methamphetamine (aOR 1.27, 95%CI 1.22 - 1.32) and CUD (aOR 1.53, 95%CI 1.50 - 1.56) had increased odds for hospitalization for BP mania.
CUD increases the odds for hospitalization for BP manic episode by 53%. Due to the rising prevalence of cannabis use among patients with BP it is important to provide substance use counseling/psychoeducation and discourage cannabis use among youth to prevent long-term adverse consequences.
评估因 cannabis 使用障碍（CUD）导致双相情感障碍（BP）躁狂和抑郁相关住院的几率。
我们使用国家住院患者样本（NIS）进行了一项横断面研究，纳入了按躁狂症（N=209785）与抑郁症发作（N=170480）分组的成年 BP 住院患者亚组。使用逻辑回归模型评估 CUD 与 BP 躁狂症相关住院之间的关联的调整比值比（aOR），并调整了人口统计学混杂因素、精神共病和其他物质使用障碍（SUD）。
与 BP 抑郁症相比，BP 躁狂症的合并症发生率较低：焦虑障碍（22.7% vs. 35.3%）、创伤后应激障碍（8.7% vs. 14.3%）和人格障碍（15.4% vs. 20.5%）。在 SUD 中，冰毒（aOR 1.27，95%CI 1.22-1.32）和 CUD（aOR 1.53，95%CI 1.50-1.56）的住院几率增加。
CUD 使 BP 躁狂发作住院的几率增加了 53%。由于 BP 患者中大麻使用的流行率不断上升，为防止长期不良后果，为青少年提供物质使用咨询/心理教育并劝阻大麻使用非常重要。
