Department of Liver Surgery and Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
School of Computer Science, Northwestern Polytechnical University, Xi'an, China.
J Hematol Oncol. 2021 Dec 11;14(1):205. doi: 10.1186/s13045-021-01195-y.
Understanding the adjacent liver microenvironment of hepatocellular carcinoma (HCC) with possible metastasis tendency might provide a strategy for risk classification of patients and potential therapies by converting the unique metastasis-inclined microenvironment to a metastasis-averse one. In this study, we performed an integrated proteogenomic analysis to have a comprehensive view on the heterogeneity of hepatic microenvironment contributing to HCC metastasis. Pairing mRNA-protein analysis revealed consistent and discordant mRNA-protein expressions in metabolism regulations and cancer-related pathways, respectively. Proteomic profiling identified three subgroups associated with the recurrence-free survival of patients. These proteomic subgroups demonstrated distinct features in metabolic reprogramming, which was potentially modified by epigenetic alterations. This study raises the point of metabolic heterogeneity in HCC noncancerous tissues and may offer a new perspective on HCC treatment.
了解具有潜在转移倾向的肝细胞癌（HCC）的邻近肝微环境，可能通过将独特的转移倾向微环境转化为转移抵抗性微环境，为患者的风险分类和潜在治疗提供策略。在这项研究中，我们进行了综合的蛋白质基因组分析，以全面了解促进 HCC 转移的肝微环境异质性。mRNA-蛋白质分析配对揭示了代谢调节和癌症相关途径中一致和不一致的 mRNA-蛋白质表达。蛋白质组学分析确定了与患者无复发生存相关的三个亚组。这些蛋白质组亚组在代谢重编程方面表现出不同的特征，这可能是由表观遗传改变修饰的。本研究提出了 HCC 非癌组织中代谢异质性的观点，并可能为 HCC 治疗提供新的视角。
