Merluzzi V J, Smith M D, Last-Barney K
Cell Immunol. 1986 Jul;100(2):563-9. doi: 10.1016/0008-8749(86)90054-7.
Pretreatment of mice with rabbit anti-asialo GM1 removes both natural killer (NK) effector cells and NK cells responsive to interleukin 2 (IL-2). Spleen cells from these mice do possess normal lymphokine-activated killer (LAK) activity. Young mice (less than 3 weeks of age) do not have NK activity and do not possess IL-2-inducible NK effector cells. Similarly to anti-asialo GM1-treated mice, LAK cells can be generated from these mice. While these experiments indicate clear distinctions between a certain level of NK and LAK precursors, the distinctions are not as clear when analyzing mice congenitally deficient in NK cells. Beige mice which lack NK effector cells and IL-2-inducible NK cells also lack the ability to generate LAK cells. The relationships and differences between NK- and LAK-cell precursors and effectors are discussed.
用兔抗去唾液酸GM1对小鼠进行预处理，可去除天然杀伤（NK）效应细胞和对白介素2（IL-2）有反应的NK细胞。这些小鼠的脾细胞确实具有正常的淋巴因子激活的杀伤（LAK）活性。幼鼠（小于3周龄）没有NK活性，也不具有IL-2诱导的NK效应细胞。与抗去唾液酸GM1处理的小鼠相似，这些小鼠也能产生LAK细胞。虽然这些实验表明一定水平的NK和LAK前体之间存在明显差异，但在分析先天性NK细胞缺陷的小鼠时，这种差异并不那么明显。缺乏NK效应细胞和IL-2诱导的NK细胞的米色小鼠也缺乏产生LAK细胞的能力。本文讨论了NK细胞和LAK细胞前体与效应细胞之间的关系和差异。
