Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Department of Cardiology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Nutr Metab Cardiovasc Dis. 2022 Feb;32(2):469-478. doi: 10.1016/j.numecd.2021.10.018. Epub 2021 Nov 5.
The relationship between hemoglobin glycation index (HGI) and the diagnosis and prognosis of cardiovascular disease (CVD) has been verified by previous studies. However, it remains unknown whether HGI has a predictive effect on subclinical myocardial injury (SC-MI). The purpose of the present study was to explore the relationship between HGI and SC-MI in the general population free from CVD.
The present study included 6009 participants free of CVD from the third National Health and Nutrition Examination Survey. Binary Logistic regression analysis was used to tested the association between HGI and SC-MI. As results, the HGI was significantly higher in participants with SC-MI compared with those without, and the HGI was positively correlated with SC-MI and other metabolic disorder parameters. Each 1-unit increase of HGI and glycated hemoglobin A1c (HbA1c) was independently associated with higher risk of SC-MI (P < 0.05), while fasting plasma glucose (FPG) was no longer a predictive indicator of SC-MI with the increase of confounding factors [OR (95% CI): 1.001 (0.999-1.003), P = 0.305]. And in the subgroup analysis, HGI, only in participants without diabetes, was independently associated with higher risk of SC-MI, while HbA1c and FPG had no independent predictive role in both diabetic and non-diabetic participants.
HGI was a significant predictor of SC-MI in the general population free from CVD.
先前的研究已经验证了血红蛋白糖化指数（HGI）与心血管疾病（CVD）的诊断和预后之间的关系。然而，HGI 是否对亚临床心肌损伤（SC-MI）具有预测作用仍不清楚。本研究旨在探讨无 CVD 的普通人群中 HGI 与 SC-MI 之间的关系。
本研究纳入了来自第三次全国健康和营养调查的 6009 名无 CVD 的参与者。采用二元 Logistic 回归分析检验 HGI 与 SC-MI 之间的关系。结果显示，患有 SC-MI 的参与者的 HGI 明显高于无 SC-MI 的参与者，并且 HGI 与 SC-MI 及其他代谢紊乱参数呈正相关。HGI 和糖化血红蛋白 A1c（HbA1c）每增加 1 个单位，与 SC-MI 的风险增加独立相关（P<0.05），而空腹血糖（FPG）随着混杂因素的增加不再是 SC-MI 的预测指标[OR（95%CI）：1.001（0.999-1.003），P=0.305]。在亚组分析中，仅在无糖尿病的参与者中，HGI 与 SC-MI 的风险增加独立相关，而 HbA1c 和 FPG 在糖尿病和非糖尿病参与者中均无独立的预测作用。
HGI 是无 CVD 的普通人群中 SC-MI 的重要预测指标。
