Department of Endocrinology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
Department of Clinical Nutrition, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, 223300, Jiangsu, China.
Biol Trace Elem Res. 2024 Mar;202(3):878-884. doi: 10.1007/s12011-023-03727-8. Epub 2023 Jun 9.
The data for the effect of dietary magnesium (Mg) on hemoglobin glycation index (HGI) is limited. Thus, this study aimed to examine the relationship between dietary Mg and HGI in the general population. Our research used data from the National Health and Nutrition Examination Survey from 2001 to 2002. The dietary intake of Mg was assessed by two 24-h dietary recalls. The predicted HbA1c was calculated based on fasting plasma glucose. Logistic regression and restricted cubic spline models were applied to assess the relationship between dietary Mg intake and HGI. We found a significant inverse association between dietary Mg intake and HGI (β = - 0.00016, 95%CI: - 0.0003, - 0.00003, P = 0.019). Dose-response analyses revealed that HGI decreased with increasing intakes of Mg when reached the point above 412 mg/day. There was a linear dose-response relationship between dietary Mg intake and HGI in diabetic subjects, and there was an L-shape dose-response relationship in non-diabetic individuals. Increasing the intake of Mg might help lower the risk associated with high HGI. Further prospective studies are requested before dietary recommendations.
关于饮食镁（Mg）对血红蛋白糖化指数（HGI）的影响的数据有限。因此，本研究旨在探讨一般人群中饮食镁与 HGI 之间的关系。我们的研究使用了 2001 年至 2002 年国家健康和营养检查调查的数据。通过两次 24 小时膳食回忆来评估 Mg 的膳食摄入量。根据空腹血糖计算预测的 HbA1c。应用逻辑回归和限制立方样条模型来评估饮食镁摄入量与 HGI 之间的关系。我们发现饮食镁摄入量与 HGI 之间存在显著的负相关关系（β=-0.00016，95%CI：-0.0003，-0.00003，P=0.019）。剂量反应分析显示，当镁摄入量超过 412mg/天时，HGI 随镁摄入量的增加而降低。在糖尿病患者中，饮食镁摄入量与 HGI 之间存在线性剂量反应关系，而在非糖尿病患者中存在 L 形剂量反应关系。增加镁的摄入量可能有助于降低与高 HGI 相关的风险。在提出饮食建议之前，需要进行更多的前瞻性研究。
