Westmead Hospital, Westmead, Sydney, New South Wales, Australia.
Westmead Hospital, Westmead, Sydney, New South Wales, Australia; Westmead and Central Clinical Schools, Discipline of Clinical Ophthalmology and Eye Health, The University of Sydney, Sydney, New South Wales, Australia; The University of New South Wales, Sydney, New South Wales, Australia; Save Sight Institute, Sydney Medical School, University of Sydney, New South Wales, Australia.
Surv Ophthalmol. 2022 Jul-Aug;67(4):1081-1098. doi: 10.1016/j.survophthal.2021.12.001. Epub 2021 Dec 8.
Glaucoma is a chronic optic neuropathy that creates a significant burden on public health. Oxidative stress is hypothesized to play a role to glaucoma progression, and its reduction is being analyzed as a therapeutic target. Dietary antioxidants play a crucial role in helping provide insight into this hypothesis. We reviewed 71 trials, interventional, in-vivo and Iin vitro, including 11 randomized controlled trials, to determine if adjunctive nutritional supplementation could lead to a reduction in oxidative stress and prevent glaucomatous progression. Many laboratory findings show that vitamins and natural compounds contain an abundance of intrinsic antioxidative, neuroprotective and vasoprotective properties that show promise in the treatment and prevention of glaucoma. Although there is encouraging early evidence, most clinical findings are inconclusive. The group of B vitamins appear to have the greatest amount of evidence. Other compounds such as flavonoids, carotenoids, curcumin, saffron, CoQ10, gingko biloba, and resveratrol however warrant further investigation in glaucoma patients. Studies of these antioxidants and other nutrients could create adjunctive or alternative preventative and treatment modalities for glaucoma to those currently available.
青光眼是一种慢性视神经病变，对公共卫生造成了重大负担。氧化应激被认为在青光眼的进展中起作用，其减少被分析为一个治疗靶点。膳食抗氧化剂在帮助提供对这一假设的深入了解方面发挥着至关重要的作用。我们回顾了 71 项干预性、体内和体外的试验，包括 11 项随机对照试验，以确定辅助营养补充是否可以减少氧化应激并预防青光眼的进展。许多实验室研究结果表明，维生素和天然化合物含有丰富的内在抗氧化、神经保护和血管保护特性，在治疗和预防青光眼方面有很大的希望。尽管有令人鼓舞的早期证据，但大多数临床研究结果尚无定论。B 族维生素组似乎有最多的证据。然而，其他化合物，如类黄酮、类胡萝卜素、姜黄素、藏红花、CoQ10、银杏叶和白藜芦醇，在青光眼患者中值得进一步研究。这些抗氧化剂和其他营养素的研究可以为青光眼提供辅助或替代的预防和治疗方法，以替代目前可用的方法。
