Hirota K, Momose Y, Takeda R, Nakanishi S, Ito Y
Eur J Pharmacol. 1986 Jul 31;126(3):293-5. doi: 10.1016/0014-2999(86)90060-9.
Halothane has been shown to produce significant changes in heart rate and strength of contraction. We have studied the mechanism(s) of these effects by recording action potentials and transmembrane ionic currents in single cardiac cells from bullfrog atrium. Our results show that the action potential was prolonged and its plateau was depressed; and that there was a significant inhibition of a potassium current, Ik, and a Ca2+ current, Isi, following halothane (2%) application.
