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SARS-CoV-2 肺炎合并骨髓增生异常综合征并发铜绿假单胞菌感染。

SARS-Cov-2 pneumonia and concurrent myelodysplasia complicated by Pseudomonas aeruginosa over-infection.

机构信息

Cardiovascular-Respiratory Science Department, Sant'Andrea Hospital-Sapienza University, Via di Grottarossa, 1035/39, 00189, Rome, Italy.

Department of Neurosciences, Mental Health and Sensory Organs [NESMOS], Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy.

出版信息

J Virol Methods. 2022 Feb;300:114419. doi: 10.1016/j.jviromet.2021.114419. Epub 2021 Dec 10.

Abstract

The new virus called severe acute respiratory syndrome coronavirus 2 (SARSCov-2) causing Coronavirus disease 2019 (COVID-19) has spread quickly in several countries and it has become pandemic. Different types of clinical manifestations are attributed to this infection. Some mechanisms related to the infection regarding the immune response are not still elucidated. Herein we reported a case of a 66-years-old patient affected by myelodysplasia who was referred to our hospital because of clinical and radiological manifestations of viral pneumonia. The clinical course has become complicated due to bacterial secondary over-infection by Pseudomonas aeruginosa during stay in internal medicine unit whilst a persistent positive oral and naso-pharyngeal swab test was reported up to 100 days of admission. The patient had a fast clinical and radiological worsening that led her to be admitted to an intensive care unit. Despite intubation and mechanical ventilation she died in a few days.

摘要

新型冠状病毒(SARS-CoV-2)引发的 2019 年冠状病毒病(COVID-19)已在多个国家迅速传播,并已成为大流行。这种感染可导致不同类型的临床表现。感染相关的免疫反应的一些机制尚不清楚。在此,我们报告了一例 66 岁的骨髓增生异常综合征患者,因病毒性肺炎的临床和影像学表现而被转至我院。由于在入住内科期间继发铜绿假单胞菌细菌感染,该患者的临床病程变得复杂,入院 100 天内持续报告口腔和鼻咽拭子检测阳性。患者的临床和影像学迅速恶化,导致她被收入重症监护病房。尽管进行了插管和机械通气,但她几天后还是死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f2/8660133/5f2e1184d414/gr1_lrg.jpg

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