Yue Hongmei, Bai Xue, Wang Jitao, Yu Qin, Liu Weiying, Pu Jiayuan, Wang Xiaoya, Hu Jianming, Xu Dan, Li Xiaoguo, Kang Ning, Li Long, Lu Wenqiang, Feng Tao, Ding Lihui, Li Xun, Qi Xiaolong
Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China; CHESS Center, The First Hospital of Lanzhou University, Lanzhou, China.
Department of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.
Ann Palliat Med. 2020 Jul;9(4):1404-1412. doi: 10.21037/apm-20-887. Epub 2020 Jul 13.
The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has outbreak in the world. Little is known about the clinical characteristics of patients with SARS-CoV-2 infection in the high-altitude region of China. We reported the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) in Gansu province, China.
In this retrospective study, patients with laboratory-confirmed SARS-CoV-2 infection were consecutively enrolled from January 21, 2020 to February 11, 2020. The information on the epidemiological, clinical characteristics, laboratory tests, radiological features on admission, treatment and outcome were obtained with the final follow-up of March 13, 2020. On the basis of the median length of hospital stay, patients were further analyzed in two groups (long- vs. short-hospital stay).
Of the 86 patients of COVID-19 in 11 cities of Gansu Province, the median hospital stay was 14.0 days (interquartile rang, 11.0-19.0 days). In the overall cohort, the median age was 41.0 years (interquartile rang, 31.0-54.3 years), and 48 (55.8%) patients were female. Forty (46.5%) had a history of exposure to epidemic regions, but none exposed to the Huanan seafood market in Wuhan. Common symptoms included fever (41, 47.7%), and cough (37, 43.0%). On admission, 30 (34.9%) and 58 (67.4%) patients had leukopenia and lymphopenia. According to chest CT scans, 53 (66.3%) of 80 patients showed bilateral pneumonia, and 19 (23.8%) of 80 patients showed unilateral pneumonia. Of the 15 asymptomatic cases, 10 (66.6%) cases were found CT findings of pneumonia. Besides, there were 65 (75.6%) patients with mild and moderate type of COVID-19. All 86 patients received antiviral and traditional Chinese medicine therapy, 53 (61.6%) received antibacterial therapy, and 3 (3.5%) patients received invasive ventilator mechanical ventilation. The proportion of patients received antibiotic treatment in long-hospital stay group was significantly higher than that in the short-hospital stay group (P=0.045). As of March 13, 2020, 84 (97.7%) patients were discharged, and two (2.3%) cases died.
In the Gansu province cohort of 86 patients of COVID-19, most patients were with mild or moderate type, and most asymptomatic cases showed CT imaging findings of SARS-CoV-2 related pneumonia.
新型冠状病毒，即严重急性呼吸综合征冠状病毒2（SARS-CoV-2），已在全球爆发。对于中国高海拔地区感染SARS-CoV-2患者的临床特征知之甚少。我们报告了中国甘肃省2019冠状病毒病（COVID-19）患者的临床特征。
在这项回顾性研究中，2020年1月21日至2020年2月11日连续纳入实验室确诊的SARS-CoV-2感染患者。收集了流行病学、临床特征、实验室检查、入院时的放射学特征、治疗及转归信息，并于2020年3月13日进行了最终随访。根据住院时间中位数，将患者进一步分为两组（住院时间长组与住院时间短组）进行分析。
甘肃省11个城市的86例COVID-19患者中，住院时间中位数为14.0天（四分位数间距为11.0 - 19.0天）。在整个队列中，年龄中位数为41.0岁（四分位数间距为31.0 - 54.3岁），48例（55.8%）为女性。40例（46.5%）有疫区暴露史，但均未暴露于武汉华南海鲜市场。常见症状包括发热（41例，47.7%）和咳嗽（37例，43.0%）。入院时，30例（34.9%）患者白细胞减少，58例（67.4%）患者淋巴细胞减少。根据胸部CT扫描，80例患者中的53例（66.3%）表现为双侧肺炎，80例患者中的19例（23.8%）表现为单侧肺炎。15例无症状病例中，10例（66.6%）胸部CT有肺炎表现。此外，65例（75.6%）患者为轻型和中型COVID-19。86例患者均接受了抗病毒及中药治疗，53例（61.6%）接受了抗菌治疗，3例（3.5%）患者接受了有创呼吸机机械通气。住院时间长组接受抗生素治疗的患者比例显著高于住院时间短组（P = 0.045）。截至2020年3月13日，84例（97.7%）患者出院，2例（2.3%）死亡。
在甘肃省86例COVID-19患者队列中，大多数患者为轻型或中型，大多数无症状病例胸部CT有SARS-CoV-2相关肺炎影像学表现。
