Joint Laboratory of Advanced Biomedical Materials (NFU-UGent), Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Nanjing Forestry University, Nanjing 210037, PR China.
Translational Cell and Tissue Research Unit, Department of Imaging and Pathology, KU Leuven, Herestraat 49, B3000 Leuven, Belgium.
Adv Colloid Interface Sci. 2022 Jan;299:102568. doi: 10.1016/j.cis.2021.102568. Epub 2021 Nov 24.
Core-shell microparticles, composed of solid, liquid, or gas bubbles surrounded by a protective shell, are gaining considerable attention as intelligent and versatile carriers that show great potential in biomedical fields. In this review, an overview is given of recent developments in design and applications of biodegradable core-shell systems. Several emerging methodologies including self-assembly, gas-shearing, and coaxial electrospray are discussed and microfluidics technology is emphasized in detail. Furthermore, the characteristics of core-shell microparticles in artificial cells, drug release and cell culture applications are discussed and the superiority of these advanced multi-core microparticles for the generation of artificial cells is highlighted. Finally, the respective developing orientations and limitations inherent to these systems are addressed. It is hoped that this review can inspire researchers to propel the development of this field with new ideas.
核壳型微球是由固体、液体或气体泡囊被保护层所包裹而形成的，作为智能且多功能的载体备受关注，在生物医学领域具有很大的应用潜力。本综述概述了近年来在可生物降解的核壳系统的设计和应用方面的进展。讨论了几种新兴的方法，包括自组装、气体剪切和同轴电喷，并且详细强调了微流控技术。此外，还讨论了核壳型微球在人工细胞、药物释放和细胞培养应用中的特性，并强调了这些先进的多核微球在人工细胞生成方面的优势。最后，讨论了这些系统所固有的各自发展方向和局限性。希望本综述能够为研究人员提供新的思路，推动该领域的发展。
