Professor, Department of Neurology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mult Scler Relat Disord. 2022 Jan;57:103441. doi: 10.1016/j.msard.2021.103441. Epub 2021 Dec 4.
Multiple Sclerosis (MS) is a costly burdensome nervous system disorder leading several disabilities in young and middle-aged people. Knowing MS clinical, epidemiologic and demographic characteristics may help to estimate and predict the required health services and medication facilities for the affected people. This study was aimed to determine the prevalence of MS and its demographic characteristic in about 2 million Kurdish populations in western Iran in 2020.
This cross-sectional study was conducted in 2020 on MS patients with Kurdish Ethnicity living in Kermanshah /western Iran which is a Mountainous area in. MS patients were registered and recruited to this study from several centers. The settings have been approved by the nationwide MS registry of Iran (NMSRI). Using two questioners, a questionnaire included sex, age, the age in which the MS symptoms onset, the age of diagnosis, family history of MS, and type of MS, and second one was the Expanded Disability Status Scale (EDSS) checklist. The demographic information of Kermanshah province was adopted from the Statistical Center of Iran. In addition to descriptive statistics, U-Mann-Whitney and Chi-square tests were also used.
A total of 1557 MS patients with a mean age (±SD) of 38.66 ± 9.9 years were recruited in this study. Of them, 1216 (78.1%) were female. The majority of patients, 300 patients (19.3%), were in the age range 35-39 years, and the highest prevalence (184.82 per 100,000 populations) was observed in the age range 40-44 years. The prevalence of MS in Kermanshah province is estimated 79.50 per 100,000 people, 125.71 per 100,000 in female and 34.41 per 100,000 in male. This prevalence was higher in female (female to male was 3.65 to 1). The EDSS score was significantly higher in male than in female (3.06 ± 2.2 in male versus 2.42 ± 1.8 in female) (p = 0.001). The type of MS was significantly different between male and female, so that SPMS and PPMS were more common in male (31(10.3%), 22(7.3%)) than female (81(7.5%), 39(3.6%)) (p = 0.012). A positive family history of MS was found in 12.6% of patients.
Given the information about prevalence of MS in Kermanshah (in 2012), the prevalence of MS in Kermanshah has increased during last decade. MS disabilities were more extensive in male rather than female.
多发性硬化症（MS）是一种代价高昂且负担沉重的神经系统疾病，会导致年轻和中年人群出现多种残疾。了解 MS 的临床、流行病学和人口统计学特征，有助于评估和预测受影响人群所需的医疗服务和药物设施。本研究旨在确定 2020 年伊朗西部约 200 万库尔德人群中 MS 的患病率及其人口统计学特征。
这是一项 2020 年在伊朗西部克尔曼沙阿/山区的库尔德族 MS 患者中进行的横断面研究。MS 患者从多个中心被登记和招募到这项研究中。该研究得到了伊朗全国多发性硬化症注册中心（NMSRI）的批准。研究人员使用了两份问卷，一份问卷包括性别、年龄、MS 症状发病年龄、诊断年龄、MS 家族史和 MS 类型，另一份是扩展残疾状况量表（EDSS）检查表。克尔曼沙阿省的人口统计信息取自伊朗统计中心。除了描述性统计外，还使用了 U- Mann-Whitney 和卡方检验。
本研究共纳入了 1557 名平均年龄（±标准差）为 38.66±9.9 岁的 MS 患者。其中，1216 名（78.1%）为女性。大多数患者（300 名，19.3%）处于 35-39 岁年龄组，发病率最高（每 10 万人中有 184.82 人）出现在 40-44 岁年龄组。估计克尔曼沙阿省的 MS 患病率为每 10 万人中有 79.50 人，女性为每 10 万人中有 125.71 人，男性为每 10 万人中有 34.41 人。女性的患病率高于男性（女性与男性的比例为 3.65 比 1）。男性的 EDSS 评分明显高于女性（男性为 3.06±2.2，女性为 2.42±1.8）（p=0.001）。MS 类型在男女之间存在显著差异，因此 SPMS 和 PPMS 在男性中更为常见（31 例（10.3%），22 例（7.3%）），而在女性中更为常见（81 例（7.5%），39 例（3.6%））（p=0.012）。在 12.6%的患者中发现了 MS 的阳性家族史。
考虑到克尔曼沙阿的 MS 患病率信息（2012 年），克尔曼沙阿的 MS 患病率在过去十年中有所增加。男性的 MS 残疾程度比女性更为广泛。
