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工人长期随机摄入的生物测定。

Bioassays in workers exposed to long time random intakes.

机构信息

Universidad de Salamanca, Spain.

CIEMAT - Unidad de Dosimetría de Radiaciones, Spain.

出版信息

Appl Radiat Isot. 2022 Feb;180:110057. doi: 10.1016/j.apradiso.2021.110057. Epub 2021 Dec 4.

DOI:10.1016/j.apradiso.2021.110057
PMID:34896900
Abstract

Workers who are occupationally exposed to radioactive aerosols are usually subjected to periodic controls of internal contamination by performing bioassays (whole body or partial body monitoring and measurement of excreta samples). The intakes are also estimated by using Static Air Samples (SAS). These measurements are used to estimate the radioactive intakes of the workers. A typical assumption is the workers are chronically (constant) exposed for long periods of time. However, the intakes are random and there are also periods without any exposure (weekends, holidays, etc.). The method presented here considers both facts. Simulations help to choose the most appropriate method of evaluation to minimize the statistical uncertainties in the intake. It has been applied to evaluate workers exposed to UO2 aerosols for a long time (30 years or more for most of them) in the same working area (sintering). Results of measurements of uranium in urine and daily intakes (from SAS) of these workers have been used. For this evaluation, the new Occupational Intakes of Radionuclides (OIR) biokinetic models of the International Commission on Radiological Protection (ICRP) for uranium have been solved. For some workers the evaluation gives a significative deviation between the intake estimated from urine samples and the intake estimated using the SAS values, supporting the idea that the physiological standard parameters of the reference worker are not always applicable. The computations have been implemented in the BIOKMOD code.

摘要

从事放射性气溶胶职业接触的工人通常需要通过生物检测(全身或局部监测和排泄物样本测量)来定期进行内部污染控制。摄入量也可以通过静态空气样本(SAS)进行估计。这些测量用于估算工人的放射性摄入量。一个典型的假设是工人长期(恒定)暴露在很长一段时间内。然而,摄入量是随机的,也有一段时间没有任何暴露(周末、节假日等)。这里提出的方法考虑到了这两个事实。模拟有助于选择最合适的评估方法,以最大限度地减少摄入量的统计不确定性。它已被应用于评估在同一工作区域(烧结)中长时间(大多数人超过 30 年)接触 UO2 气溶胶的工人。已使用尿中铀的测量结果和这些工人的每日摄入量(来自 SAS)进行了评估。对于这种评估,解决了国际辐射防护委员会(ICRP)新的职业放射性核素摄入量(OIR)生物动力学模型中铀的问题。对于一些工人,评估结果显示,通过尿液样本估算的摄入量与通过 SAS 值估算的摄入量之间存在显著差异,这支持了这样一种观点,即参考工人的生理标准参数并不总是适用。计算是在 BIOKMOD 代码中实现的。

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引用本文的文献

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