The Turner Institute for Brain and Mental Health, School of Psychological Sciences, and Monash Biomedical Imaging, Monash University, Victoria, Australia; Developmental Imaging, Murdoch Children's Research Institute, Victoria, Australia.
Developmental Imaging, Murdoch Children's Research Institute, Victoria, Australia; Department of Paediatrics, University of Melbourne, Victoria, Australia.
Curr Opin Psychol. 2022 Apr;44:321-329. doi: 10.1016/j.copsyc.2021.10.010. Epub 2021 Nov 13.
Human brain networks undergo pronounced changes during development. The emergence of highly connected hub regions that can support integrated brain function is central to this maturational process, with these areas undergoing a particularly protracted period of development that extends into adulthood. The location of cortical network hubs emerges early but connections to and from hubs continue to strengthen throughout childhood and adolescence. Patterns of functional coupling in cortical association hubs are immature and incomplete at birth, but gradually strengthen during development. Early establishment of hub connectivity may provide a stable substrate that is refined by changes in tissue organization and microstructure, resulting in the emergence of complex functional dynamics by adulthood.
人类大脑网络在发育过程中会发生显著变化。高度连接的枢纽区域的出现是成熟过程的核心，这些区域经历了一个特别漫长的发育阶段，一直持续到成年。皮质网络枢纽的位置很早就出现了，但与枢纽的连接在儿童期和青春期仍在继续加强。皮质联合枢纽的功能耦合模式在出生时不成熟且不完整，但在发育过程中逐渐增强。枢纽连接的早期建立可能为组织和微观结构变化提供一个稳定的基础，从而在成年时产生复杂的功能动力学。
