Hatanaka Takeshi, Kakizaki Satoru, Kaburagi Takuya, Saito Naoto, Nakano Sachi, Hazama Yoichi, Yoshida Sachiko, Hachisu Yoko, Tanaka Yoshiki, Yoshinaga Teruo, Kashiwabara Kenji, Naganuma Atsushi, Yamazaki Yuichi, Uraoka Toshio, Nagashima Shigeo, Takahashi Masaharu, Nishizawa Tsutomu, Murata Kazumoto, Okamoto Hiroaki
Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital, Japan.
Department of Clinical Research, National Hospital Organization Takasaki General Medical Center, Japan.
Intern Med. 2022 May 15;61(10):1537-1543. doi: 10.2169/internalmedicine.8673-21. Epub 2021 Dec 11.
A 66-year-old man, who had undergone plasma exchange 30 years previously in Egypt for the treatment of falciparum malaria, was referred to our hospital for treatment of chronic hepatitis C (HCV). An analysis of the 655-nucleotide 5'-untranslated region-core region sequence revealed infection with HCV subtype 1g. A phylogenetic analysis of the full-length HCV genome confirmed that the patient's HCV was subtype 1g, which was the first case identified in Japan. Although his HCV possessed several naturally occurring resistance-associated substitutions in the nonstructural (NS) 3 and NS5A regions, he was successfully treated by combination therapy with glecaprevir/pibrentasvir.
一名66岁男性，30年前在埃及接受过血浆置换以治疗恶性疟原虫疟疾，现因慢性丙型肝炎（HCV）被转诊至我院。对655个核苷酸的5'非翻译区-核心区序列分析显示感染了HCV 1g亚型。对HCV全长基因组进行系统发育分析证实该患者的HCV为1g亚型，这是日本首例确诊病例。尽管其HCV在非结构（NS）3区和NS5A区有多个自然发生的耐药相关置换，但通过glecaprevir/pibrentasvir联合治疗，他获得了成功治愈。
