不同制造商生产的白喉、破伤风和百日咳联合疫苗在实验动物和婴儿中的比较。
A comparison of combined diphtheria, tetanus and pertussis vaccines produced by different manufacturers, in laboratory animals and in infants.
作者信息
Nyerges G, Adám M M, Gács P, Ring R
出版信息
J Biol Stand. 1986 Jul;14(3):241-7. doi: 10.1016/0092-1157(86)90009-0.
Three DTP vaccines were investigated for potency and toxicity (reactogenicity) both in laboratory animals and in infants. Animal tests were carried out in conformity with the WHO recommendations. Three- to five-month-old infants were investigated for their specific antibody responses and for local and systemic vaccination reactions. No correlation was found between the potency values of the vaccines as expressed in IUs and the antibody titres of the vaccinated infants. The most striking difference between the human and animal responses to vaccination was observed in the case of the tetanus toxoid. The severity of the vaccination reactions in infants correlated with the toxicity of the vaccines as assessed in the mouse weight gain test (MWGT) carried out in CBA mice. No correlation was found, however when conventional or AKR mice were used in the MWGT.
在实验动物和婴儿中对三种白百破疫苗的效力和毒性（反应原性）进行了研究。动物试验按照世界卫生组织的建议进行。对3至5个月大的婴儿进行了特异性抗体反应以及局部和全身疫苗接种反应的调查。未发现以国际单位表示的疫苗效力值与接种疫苗婴儿的抗体滴度之间存在相关性。在破伤风类毒素的情况下，观察到人与动物对疫苗接种反应的最显著差异。婴儿接种反应的严重程度与在CBA小鼠中进行的小鼠体重增加试验（MWGT）评估的疫苗毒性相关。然而，当在MWGT中使用常规小鼠或AKR小鼠时，未发现相关性。
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