了解孕期抗生素的药代动力学：治疗药物监测是否有作用？一篇叙述性综述。
Understanding the Pharmacokinetics of Antibiotics in Pregnancy: Is There a Role for Therapeutic Drug Monitoring? A Narrative Review.
机构信息
Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, Australia.
Interdisciplinary Centre for Health Studies (CIESAL), Universidad de Valparaíso, Valparaíso, Chile.
出版信息
Ther Drug Monit. 2022 Feb 1;44(1):50-64. doi: 10.1097/FTD.0000000000000950.
PURPOSE
Antibiotics are commonly used during pregnancy. However, physiological changes during pregnancy can affect the pharmacokinetics of drugs, including antibiotics, used during this period. Pharmacokinetic evaluations have shed light on how antibiotics are affected during pregnancy and have influenced dosing recommendations in this context.
METHODS
A narrative review was conducted and included reports providing data reflecting drug distribution and exposure in the context of pregnancy.
RESULTS
Pharmacokinetic parameters of antibiotics in pregnancy and transplacental passage of antibiotics are comprehensively presented.
CONCLUSIONS
Knowledge about the impact on pharmacokinetics and fetal exposure is especially helpful for complicated or severe infections, including intra-amniotic infection and sepsis in pregnancy, where both mother and fetus are at risk. Further studies are warranted to consolidate the role of therapeutic drug monitoring in complicated or severe infections in pregnant patients.
目的
抗生素在怀孕期间通常被使用。然而，怀孕期间的生理变化会影响药物的药代动力学，包括在此期间使用的抗生素。药代动力学评估揭示了抗生素在怀孕期间如何受到影响，并影响了这方面的剂量建议。
方法
进行了叙述性综述，其中包括提供反映药物在妊娠期间分布和暴露数据的报告。
结果
全面介绍了怀孕期间抗生素的药代动力学参数和抗生素的胎盘转运。
结论
了解对药代动力学和胎儿暴露的影响对于复杂或严重感染特别有帮助，包括宫内感染和妊娠时的败血症，此时母亲和胎儿都有风险。需要进一步的研究来巩固治疗药物监测在复杂或严重感染孕妇中的作用。
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